Identification of intrinsic in vitro cellular mechanisms for glioma invasion

Journal of Theoretical Biology
Marco TektonidisAndreas Deutsch


Invasion of malignant glioma is a highly complex phenomenon involving molecular and cellular processes at various spatio-temporal scales, whose precise interplay is still not fully understood. In order to identify the intrinsic cellular mechanisms of glioma invasion, we study an in vitro culture of glioma cells. By means of a computational approach, based on a cellular automaton model, we compare simulation results to the experimental data and deduce cellular mechanisms from microscopic and macroscopic observables (experimental data). For the first time, it is shown that the migration/proliferation dichotomy plays a central role in the invasion of glioma cells. Interestingly, we conclude that a diverging invasive zone is a consequence of this dichotomy. Additionally, we observe that radial persistence of glioma cells in the vicinity of dense areas accelerates the invasion process. We argue that this persistence results from a cell-cell repulsion mechanism. If glioma cell behavior is regulated through a migration/proliferation dichotomy and a self-repellent mechanism, our simulations faithfully reproduce all the experimental observations.


Feb 1, 1983·The Journal of Cell Biology·R A RovasioJ P Thiery
Apr 1, 1996·Neurosurgery·A GieseM Westphal
Mar 7, 1998·The Journal of Biological Chemistry·D B Batt, T M Roberts
Aug 11, 1998·International Journal of Epidemiology·P ChopardA F Junod
Jun 8, 2001·Genes & Development·E A MaherR A DePinho
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GieseM Westphal
Nov 11, 2003·Journal of the Neurological Sciences·K R SwansonEllsworth C Alvord
Mar 24, 2004·Current Opinion in Cell Biology·Peter Friedl
Jun 10, 2004·Journal of Neurobiology·Tamra WerbowetskiRolando F Del Maestro
Nov 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Joana Moreira, Andreas Deutsch
Jun 18, 2005·Medical Hypotheses·Thomas S DeisboeckPier Paolo Delsanto
Jul 11, 2006·Physical Biology·M AubertB Grammaticos
Apr 27, 2007·PloS One·Daniel StockholmAndras Paldi
May 4, 2007·NeuroImage·Hermann B FrieboesVittorio Cristini
May 16, 2007·Physical Review Letters·Sergei Fedotov, Alexander Iomin
Sep 11, 2007·Differentiation; Research in Biological Diversity·Thi My Anh Neildez-NguyenAndras Paldi
Nov 21, 2007·Journal of Mathematical Biology·Cosmina HogeaGeorge Biros
Oct 7, 2008·Biophysical Journal·Brenda M Rubenstein, Laura J Kaufman
Oct 10, 2008·Acta Biotheoretica·M AubertB Grammaticos
Jul 25, 2009·Cell Proliferation·M L TanakaI K Puri
Nov 6, 2009·Cancer Research·Heiko EnderlingPhilip Hahnfeldt
Nov 28, 2009·Mathematical Medicine and Biology : a Journal of the IMA·Arnaud ChauviereHelen M Byrne


Aug 2, 2014·Neuro-oncology·Qian XieMichael E Berens
Jan 24, 2016·Journal of Theoretical Biology·Lotte SewaltSanjeeva Balasuriya
Nov 29, 2011·Journal of Theoretical Biology·Alberto d'Onofrio
Aug 26, 2014·Bulletin of Mathematical Biology·Olivier SautHassan M Fathallah-Shaykh
Jun 16, 2015·Journal of Theoretical Biology·Marc SturrockGrzegorz A Rempala
Sep 4, 2015·PLoS Computational Biology·Katrin BöttgerAndreas Deutsch
Jul 25, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Előd Méhes, Tamás Vicsek
Nov 10, 2017·Journal of the Royal Society, Interface·J C L AlfonsoAndreas Deutsch
Sep 24, 2015·Cancer Informatics·Georgios TzedakisV Sakkalis
Feb 5, 2019·JCO Clinical Cancer Informatics·John MetzcarPaul Macklin
Mar 15, 2019·Cell Cycle·David BernardBernard Ducommun
Aug 20, 2017·Cellular and Molecular Life Sciences : CMLS·Shwetal Mehta, Costanza Lo Cascio
Apr 5, 2018·Frontiers in Physiology·Elif Ozdemir-KaynakOzlem Yesil-Celiktas
Dec 15, 2010·Current Breast Cancer Reports·Arnaud H ChauviereVittorio Cristini
Feb 18, 2017·Bulletin of Mathematical Biology·Lu PengMark A J Chaplain
Jul 28, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yangjin KimSean Lawler
Jan 11, 2019·Convergent Science Physical Oncology·Rebecca L KlankDavid J Odde
Jan 9, 2021·Frontiers in Cell and Developmental Biology·Marina B CuencaHernan E Grecco
Mar 6, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tijana StankovićMilica Pešić
Feb 7, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sergei FedotovLev Ryashko

Related Concepts

Brain Tumor, Recurrent
Cell Motility
Mixed Gliomas
Neoplasm Invasiveness
Tumor Cells, Cultured
Spheroids, Cellular
Cell Proliferation
Malignant Neoplasms

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.