Identification of Key Genes and Pathways in Triple-Negative Breast Cancer by Integrated Bioinformatics Analysis

BioMed Research International
Pengzhi DongFangfang Liu

Abstract

Triple-negative breast cancer refers to breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (Her2). This study aimed to identify the key pathways and genes and find the potential initiation and progression mechanism of triple-negative breast cancer (TNBC). We downloaded the gene expression profiles of GSE76275 from Gene Expression Omnibus (GEO) datasets. This microarray Super-Series sets are composed of gene expression data from 265 samples which included 67 non-TNBC and 198 TNBC. Next, all the differentially expressed genes (DEGs) with p<0.01 and fold change ≥1.5 or ≤-1.5 were identified. 56 upregulated and 151 downregulated genes were listed and the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analysis was performed. These significantly changed genes were mainly involved in the biological process termed prostate gland morphogenesis, inner ear morphogenesis, cell maturation, digestive tract morphogenesis, autonomic nervous system development, monovalent inorganic anion homeostasis, neural crest cell development, regulation of dendrite extension and glial cell proliferation, immune system process termed T ...Continue Reading

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Citations

Aug 15, 2020·Frontiers in Oncology·Barbara SchrörsMartin Löwer
Nov 8, 2020·Journal of Bioenergetics and Biomembranes·Zhen LiuPengpeng Qu
Nov 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yuxuan WangMinghua Wu

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Datasets Mentioned

BETA
GSE76275
GEO2R

Software Mentioned

GEO2R
Morpheus
Cytoscape
Search Tool for the Retrieval of Interacting Genes / Proteins ...
Oncoprint
MCODE
ClueGO
cBioPortal

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