Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis.

Neural Regeneration Research
Yan LuQian-Qian Cao

Abstract

Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian degeneration. Therefore, investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover the molecular mechanisms and signal cascades underlying peripheral nerve repair and provide potential strategies for improving the low axon regeneration capacity of the central nervous system. In this study, we applied weighted gene co-expression network analysis to identify differentially expressed genes in proximal and distal sciatic nerve segments from rats with sciatic nerve injury. We identified 31 and 15 co-expression modules from the proximal and distal sciatic nerve segments, respectively. Functional enrichment analysis revealed that the differentially expressed genes in proximal modules promoted regeneration, while the differentially expressed genes in distal modules promoted neurodegeneration. Next, we constructed hub gene networks for selected modules and identified a key hub gene, Kif22, which was up-regulated in both nerve segments. In vitro experiments confirmed that Kif22 knockdown inhibited proliferation and migration of Schwann cells by modulating the activity of th...Continue Reading

References

May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Bin Zhang, Steve Horvath
Mar 6, 2007·Journal of Neuroscience Research·Xin-Fu Zhou, Hong-Yun Li
Mar 18, 2008·Journal of Neuropathology and Experimental Neurology·Christine A WebberDouglas W Zochodne
Mar 30, 2010·Annual Review of Neuroscience·Michael P Coleman, Marc R Freeman
Oct 3, 2013·International Review of Neurobiology·Petr DubovýTomas Kubek
May 21, 2014·Nature Reviews. Neuroscience·Laura ConfortiMichael P Coleman
Jun 23, 2015·Journal of Receptor and Signal Transduction Research·Yu SunHua-Fu Zhou
Feb 13, 2016·The Journal of Physiology·K R Jessen, R Mirsky
May 7, 2016·Neuron·Zhigang He, Yishi Jin
Sep 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Miao HeZhen-Ge Luo
Feb 28, 2017·Frontiers in Cellular Neuroscience·Sheng YiXiaosong Gu
Oct 17, 2017·Developmental Neurobiology·George M Smith, Gianluca Gallo
Feb 1, 2018·Science Signaling·Rosemary PikeMaddy Parsons
Mar 16, 2018·Current Opinion in Neurobiology·Oriane Blanquie, Frank Bradke
Apr 19, 2018·Nature Reviews. Neuroscience·Marcus Mahar, Valeria Cavalli
Jul 20, 2018·Developmental Neurobiology·Marie-Pier GirouardAlyson E Fournier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.