Identification of Key Intermediates during the NO and H2 S Crosstalk Signaling Pathways

The Journal of Physical Chemistry. a
Mohamed CherakiMajdi Hochlaf

Abstract

The stable isomers and electronic states of [S,S,N,O]-species are investigated with a special focus on the most relevant isomers that could be involved in the NO/H2S cross-talk pathways in biological media. This work identifies eight stable anions, among which are the already known cis-SSNO-and trans-SSNO-molecules and a new NO3--like anionic species, NS2O-. Our computations show that the previously determined structure in lab experiment is trans-SSNO-, which is not relevant for biological activity in vivo. Instead, NS2O-is proposed as the most likely key intermediate in vivo during important biological processes. This result alleviates the corresponding controversy in the literature.

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Citations

May 21, 2020·Chemistry : a European Journal·Yingying WangMing Xian
Nov 7, 2019·Inorganic Chemistry·Juan P MarcolongoJosé A Olabe

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