Abstract
Osteosarcoma is known as a type of common human bone malignancy, and more therapeutic targets are still required to combat this disease. In recent years, the involvement of KIF2A in cancer progression has been widely revealed; however, its potential effect on osteosarcoma development remains unknown. This study is to assess the KIF2A expression levels in human osteosarcoma tissues and explore its potential role in osteosarcoma development. Immunohistochemical (IHC) assays were conducted to evaluate the expression levels of KIF2A in a total of 74 samples of osteosarcoma tissues and adjacent nontumor tissues. According to the staining intensity in tumor tissues, patients were divided into highly expressed and low expression KIF2A groups. The possible links between the KIF2A expression and the clinical pathological features were explored and analyzed, and the effects of KIF2A on osteosarcoma cell proliferation, migration, and invasion were detected through colony formation assay, MTT assay, wound closure assay, and transwell assay, respectively. The effects of KIF2A on tumor growth and metastasis were detected by the use of animal models. KIF2A was highly expressed in human osteosarcoma tissues. Meanwhile, KIF2A was obviously corr...Continue Reading
References
Jun 1, 2007·Molecular Biology of the Cell·Amity L ManningDuane A Compton
Mar 31, 2009·Current Biology : CB·Anne L KnowltonP Todd Stukenberg
Dec 17, 2009·Oral Oncology·Cheng-Qin WangShan-Zhen Sun
Jul 25, 2012·Nature Reviews. Cancer·Oliver Rath, Frank Kozielski
Feb 22, 2013·ELife·Jeremy D Wilbur, Rebecca Heald
Mar 28, 2013·Environmental and Molecular Mutagenesis·Mario FioreFrancesca Degrassi
Jun 22, 2014·BMC Cancer·Jianli WangYunyun Gong
Sep 1, 2015·PloS One·Liliana Endo-MunozNicholas A Saunders
Dec 19, 2015·Genetics and Molecular Research : GMR·W D ZhengN Lin
Dec 29, 2015·Molecular Medicine Reports·Xin ZhangXun Qu
Mar 5, 2016·Medicine·Di WangYunzhao Xu
Jun 11, 2016·Journal of Cell Science·Hye Jin KwonChang-Young Jang
Dec 20, 2016·Scientific Reports·Zi-Yun YiSong Quan
Dec 20, 2016·Scientific Reports·Ming-Huang ChenHai-Long Wang
Feb 17, 2017·OncoTargets and Therapy·Parunya ChaiyawatDumnoensun Pruksakorn
Jun 16, 2017·Annals of Hematology·Yaping ZhangWenyu Shi
Jul 16, 2017·Scientific Reports·Hao WangGuowei Zuo
Sep 14, 2017·Journal of Cancer Research and Therapeutics·Jianliang ChenGuoqiang Li
Sep 15, 2017·Oncotarget·Kai Yau WongKwok Wah Chan
Jan 10, 2018·ELife·Noriko HommaNobutaka Hirokawa
Feb 11, 2018·Biochemical and Biophysical Research Communications·Tian XieChongjun Zhong
Mar 16, 2018·Biomedical Reports·Peixuan XiaHongying Zhou
Apr 10, 2018·SICOT-J·Amirhossein MisaghiAnna A Kulidjian
May 22, 2018·Clinical and Experimental Pharmacology & Physiology·Peng ZhaoDong Liu
Sep 27, 2018·Scientific Reports·Yidan ZhangBang H Hoang
Feb 6, 2019·Oncotarget·Kenta WatanabeTomoatsu Kimura
Feb 26, 2019·Journal of Cellular Physiology·Gang LiYi Wang
Nov 28, 2019·Disease Markers·Fu-Tao Chen, Fu-Kuan Zhong