Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex

Immunogenetics
Line Mari FlornesSigbjørn Fossum

Abstract

In an experimental rat model, we recently mapped an arthritis susceptibility locus to the distal part of Chromosome 4 containing genes predicted to encode C-type lectin superfamily (CLSF) receptors. Here we report the cDNA cloning and positional arrangement of these receptor genes, which represent rat orthologues to human Mincle and DCIR and to mouse MCL and Dectin-2, as well as four novel receptors DCIR2, DCIR3, DCIR4 and DCAR1, not previously reported in other species. We furthermore report the cDNA cloning of human Dectin-2 and MCL, and of the mouse orthologues to the novel rat receptors. Similar to the killer-cell lectin-like receptors (KLR) some of these receptors exhibit structural features suggesting that they regulate leukocyte reactivity; e.g., human DCIR and rodent DCIR1 and DCIR2 carry an immunoreceptor tyrosine-based inhibitory motif (ITIM), predicting inhibitory function, and conversely, in all three species Mincle has a positively charged amino acid in the transmembrane region, suggesting activating function. Sequence comparisons show that the receptors form a discrete family, more closely related to group II CLSF receptors than to the group V KLR. Their distance to the KLR is underscored by their preservation of ...Continue Reading

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Citations

Jun 15, 2010·Immunogenetics·Line M FlornesSigbjørn Fossum
Nov 28, 2007·Cell and Tissue Research·Tomoatsu KanekoHideaki Suda
May 30, 2012·Immunology and Cell Biology·Dipti VijayanChristine A Wells
Sep 9, 2008·Nature Immunology·Sho YamasakiTakashi Saito
Sep 19, 2008·Nature Immunology·Gordon D Brown
May 30, 2008·Glycobiology·Andrea BugarcicHelen Blanchard
Apr 23, 2013·International Immunology·Bernhard KerscherGordon D Brown
Jan 29, 2011·Clinical & Developmental Immunology·Mohlopheni Jackson MarakalalaGordon D Brown
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Li HaoMasatoshi Nei
Aug 7, 2007·Cytogenetic and Genome Research·M R W MacDonaldK E Magor
Aug 1, 2007·Arthritis and Rheumatism·Johnny C LorentzenSigbjörn Fossum
Sep 14, 2007·Immunological Reviews·Hideki UenoJacques Banchereau
Jan 25, 2012·Chembiochem : a European Journal of Chemical Biology·Maho AmanoShin-Ichiro Nishimura
Aug 8, 2013·European Journal of Immunology·Ana Lobato-PascualMichael R Daws
Oct 4, 2015·Biochemical and Biophysical Research Communications·Atsushi KishimotoNaoki Matsumoto
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sho YamasakiTakashi Saito
Jun 16, 2012·Journal of Autoimmunity·Kazuhito KawataM Eric Gershwin
Aug 12, 2009·Cytokine·Lisa M Graham, Gordon D Brown
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Oct 30, 2016·Biochemical and Biophysical Research Communications·Yosuke KamedaNaoki Matsumoto
Sep 23, 2016·PloS One·Ying-Ying Hey, Helen C O'Neill
Jan 28, 2017·European Journal of Immunology·Toshifumi IshiguroKazuhiko Takahara

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