Identification of Lesional Tissues and Nonlesional Tissues in Early Gastric Cancer Endoscopic Submucosal Dissection Specimens Using a Fiber Optic Raman System

Gastroenterology Research and Practice
Zhaohui LuanGuiyong Peng

Abstract

To identify lesional and nonlesional tissues from early gastric cancer (EGC) patients by Raman spectroscopy to build a diagnostic model and effectively diagnose EGC. Specimens were collected by endoscopic submucosal dissection from 13 patients with EGC, and 55 sets of standard Raman spectral data (each integrated 10 times) were obtained using the fiber optic Raman system; there were 33 sets of lesional tissue data, including 18 sets of high-grade intraepithelial neoplasia (HGIN) data and 15 sets of adenocarcinoma data, and 22 sets of nonlesional tissue data. After the preprocessing steps, the average Raman spectrum was obtained. The nonlesional tissues showed peaks at 891 cm-1, 1103 cm-1, 1417 cm-1, 1206 cm-1, 1234 cm-1, 1479 cm-1, 1560 cm-1, and 1678 cm-1. Compared with the peaks corresponding to nonlesional tissues, the peaks of the lesional tissues shifted by different magnitudes, and a new characteristic peak at 1324 cm-1 was observed. Comparing the peak intensity ratio and the integral energy ratio of the lesional tissues with those of the nonlesional tissues revealed a significant difference between the two groups (independent-samplest-test, P < 0.05). Considering the peak intensity ratio of I1560 cm-1/I1103 cm-1 as a dia...Continue Reading

References

Aug 1, 1985·Japanese Journal of Medicine·K SegawaY Kurita
Mar 4, 2000·Physics in Medicine and Biology·E B HanlonM S Feld
Jul 3, 2003·British Journal of Cancer·P CrowM P J Wright
Mar 3, 2004·Faraday Discussions·Nicholas StoneHugh Barr
Mar 18, 2008·Photomedicine and Laser Surgery·K MaheedharC Murali Krishna
Sep 1, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hao WuXizhong Shen
Aug 24, 2010·Biosensors & Bioelectronics·Zhiwei HuangKhay Guan Yeoh
Sep 30, 2010·Acta Cirúrgica Brasileira·Andrea Fernandes de OliveiraLydia Masako Ferreira
Jun 15, 2011·Journal of Materials Science. Materials in Medicine·L L McManusB J Meenan
Mar 22, 2012·Cancer Research·Harvey LuiHaishan Zeng
Sep 3, 2013·Photodiagnosis and Photodynamic Therapy·Charlotte KallawayNick Stone
Jan 11, 2014·Lasers in Medical Science·José Luis González-SolísPascual Palomares-Anda
May 2, 2014·World Journal of Gastroenterology : WJG·Yang Won MinJae J Kim
Aug 20, 2014·Nature Reviews. Gastroenterology & Hepatology·Mairi H McLean, Emad M El-Omar
Feb 2, 2015·The Lancet Oncology·Carla OliveiraFátima Carneiro
Jul 15, 2015·World Journal of Gastroenterology : WJG·Ying-Ying HuLiang-Jing Wang
Mar 11, 2016·Nature Protocols·Holly J ButlerFrancis L Martin
May 18, 2016·World Journal of Gastrointestinal Oncology·Cerys A JenkinsDean A Harris
Sep 28, 2016·Current Problems in Surgery·Syed A AhmadAlexander A Parikh
Dec 21, 2017·Scientific Reports·Sergio LarioXavier Calvet

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Methods Mentioned

BETA
biopsy
dissection
irradiates
Raman spectroscopy

Software Mentioned

SPSS
Origin Pro

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