PMID: 6972999Jun 1, 1981Paper

Identification of leukemia-associated inhibitory activity as acidic isoferritins. A regulatory role for acidic isoferritins in the production of granulocytes and macrophages

The Journal of Experimental Medicine
H E BroxmeyerM de Sousa

Abstract

Acidic isoferritins have been identified as leukemia-associated inhibitory activity (LIA), which suppresses colony and cluster formation of colony-forming unit-granulocyte macrophages from normal donors but not from patients with leukemia. LIA was detected in all ferritin preparations tested, including ferritin isolated from normal heart, spleen, liver, and placental tissues, and from the spleens of patients with chronic myelogenous leukemia and Hodgkin's disease. Purified preparations of LIA were composed almost entirely of acidic isoferritins, as determined by immunoassay, radioimmunoassay, and isoelectric focusing. The inhibitory activity in the LIA and ferritin samples was inactivated by a battery of antisera specific for ferritin, including those prepared against acidic isoferritins from normal heart and spleen tissues from patients with Hodgkin's disease, and those previously absorbed with basic isoferritins. Antisera absorbed with acidic isoferritins did not inactivate the inhibitory activity. Separation of LIA and chronic myelogenous leukemia and normal spleen ferritin by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing confirmed that the regions of peak inhibitory activity corresponded...Continue Reading

References

Jul 1, 1979·British Journal of Haematology·Y MatznerG Izak
Oct 1, 1978·The Journal of Experimental Medicine·H E BroxmeyerM de Sousa
Aug 16, 1979·The New England Journal of Medicine·H E BroxmeyerM A Moore
Oct 27, 1978·Biochimica Et Biophysica Acta·H E Broxmeyer, M A Moore
Apr 3, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·B M Jones, M Worwood
Jul 1, 1972·Analytical Biochemistry·M C Linder, H N Munro
Dec 22, 1967·Science·K Catt, G W Tregear
Sep 25, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·B M JonesA Jacobs
Jun 1, 1980·British Journal of Haematology·M WagstaffA Jacobs
Jan 1, 1980·Annual Review of Biochemistry·P Aisen, I Listowsky
Jan 1, 1980·American Journal of Hematology·Y MatznerC Hershko

❮ Previous
Next ❯

Citations

May 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M CovellM Worwood
Mar 1, 1983·European Journal of Cancer & Clinical Oncology·M CazzolaE Ascari
Jan 1, 1988·Toxicology·J G Joshi, A Zimmerman
Dec 1, 1994·Baillière's Clinical Haematology·A M Konijn
Mar 30, 2002·Critical Reviews in Oncology/hematology·Juliana C Kwok, Des R Richardson
Dec 29, 1983·The New England Journal of Medicine·J F Desforges
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M H DörnerH N Munro
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J W ChiaoK Leung
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H E BroxmeyerP Arosio
Apr 11, 1986·Nucleic Acids Research·C SantoroL Silengo
Jan 1, 1991·Annals of the New York Academy of Sciences·A NajmanM Guigon
Jan 1, 1989·The Journal of Clinical Investigation·P WhittakerJ D Cook
Jul 31, 2013·Biochimica Et Biophysica Acta·Ahmed A Alkhateeb, James R Connor
Oct 1, 1986·Blut·H A Messner
Jan 1, 1991·Preparative Biochemistry·M Abolhassani, J W Chiao
Aug 1, 1995·Leukemia & Lymphoma·K MorikawaS Morikawa
Jan 1, 1985·Cancer Investigation·D PotaznikR B Bhalla
Jan 1, 1985·Cancer Investigation·S Zucker
Jan 15, 2008·Journal of Autoimmunity·Stefania RecalcatiGaetano Cairo
Jan 1, 1987·Critical Reviews in Oncology/hematology·G TrinchieriB Perussia
Jul 24, 2007·Autoimmunity Reviews·Gisele Zandman-Goddard, Yehuda Shoenfeld
Mar 10, 2007·Journal of Cellular Physiology·Nikolaus BresgenPeter M Eckl
Sep 1, 1988·Blood Reviews·G C Bagby
Nov 1, 1989·Journal of Internal Medicine·M Worwood

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.