PMID: 6402030Jan 7, 1983Paper

Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils

Biochimica Et Biophysica Acta
J TurkJ A Oates

Abstract

The presence of arachidonic acid lipoxygenase pathways in murine eosinophils was demonstrated by the isolation and identification of several lipoxygenase products from incubations of these cells. The most abundant arachidonate metabolite from murine eosinophils stimulated with ionophore A23187 and exogenous arachidonic acid was 12-S-hydroxyeicosatetraenoic acid (12-S-HETE), and the next most abundant was 15-HETE. Two families of leukotrienes were also recovered from these incubations. One family comprised the hydrolysis products of leukotriene A4, and the other included products derived from the 14,15-oxido analog of leukotriene A4 (14,15-leukotriene A4). Two double oxygenation products of arachidonate were also identified. These compounds were a 5,15-dihydroxyeicosatetraenoic acid (5,15-diHETE) and a 5,12-dihydroxyeicosatetraenoic acid (5,12-diHETE). Eosinophil stimulation promoter is a murine lymphokine which enhances the migration of eosinophils. When murine eosinophils were incubated with eosinophil stimulation promoter in concentrations sufficient to produce a migration response, a 2-3-fold increase in the production of 12-HETE was observed compared to unstimulated cells. Coupled with the recent demonstration that arachido...Continue Reading

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Citations

Jan 1, 1992·Veterinary Research Communications·B J McEwen
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H W ChuS E Wenzel
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T IzumiB Samuelsson
Sep 1, 1989·American Journal of Respiratory Cell and Molecular Biology·J R HansbroughM J Holtzman
May 31, 2008·American Journal of Respiratory Cell and Molecular Biology·Cecilia K AnderssonJonas S Erjefält
Aug 25, 2001·Cellular Immunology·R HoensteinF Levi-Schaffer
Aug 28, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Åsa BrunnströmHans-Erik Claesson
May 15, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E OnoK Akiyama
Jun 28, 2013·The Journal of Dermatology·Asuka YoshifukuTakuro Kanekura
Jan 29, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M JohannessonP K A Forsell
Oct 4, 2002·Archives of Biochemistry and Biophysics·Athos Ottolenghi, John T Rowland
Mar 12, 1984·FEBS Letters·J VerhagenJ F Vliegenthart
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Aug 1, 1987·Contact Dermatitis·A FigueiredoF Teixeira
Apr 1, 1985·Klinische Wochenschrift·M GoerigG Schettler
Jun 15, 1990·Biochemical and Biophysical Research Communications·A N BaerF A Green

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