Identification of loci associated with putative recurrence genes in transitional cell carcinoma of the urinary bladder

The Journal of Pathology
Joanne EdwardsJohn M S Bartlett

Abstract

Following an earlier study linking monosomy 9 with recurrence of transitional cell carcinomas (TCCs) of the urinary bladder, 109 primary and recurrent TCCs (from 47 patients) were examined to explore genetic alterations at chromosome 9 associated with recurrence. Patient DNA was microdissected and extracted from archival tissue sections and analysed for loss of heterozygosity (LOH) at three regions on chromosome 9 where tumour suppressor genes (TSGs) are known to reside (INK 4A, DBC1, and TSC1). Patients were categorized into two groups, non-recurrent TCC (NR, n=18) and recurrent TCC (REC, n=29). It was noted that 12% of NR tumours, compared with 54% of REC primary tumours (p=0.01), had LOH at all informative markers spanning the TSC1 region. The risk of recurrence was significantly higher in patients with deleted TSC1 than in those who retained the TSC1 region (p=0.035). Levels of LOH at DBC1 or INK 4A were not significantly different in NR tumours than in REC primary tumours and recurrence-free survival was not affected by loss of either of these genes. Loss of all informative markers spanning chromosome 9 was observed in 0% of NR tumours compared with 25% of REC primary tumours (p=0.04). The probability of recurrence was als...Continue Reading

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Citations

Mar 26, 2010·Expert Reviews in Molecular Medicine·Courtney PollardDan Theodorescu
Apr 10, 2008·Human Molecular Genetics·Louis S PymarMargaret A Knowles
Aug 12, 2009·Future Oncology·Liang ChengAntonio Lopez-Beltran
Jul 9, 2010·Urologic Oncology·Peter J Goebell, Margaret A Knowles
Nov 28, 2008·BJU International·Jose A KaramMargaret A Knowles
Sep 14, 2013·Critical Reviews in Oncology/hematology·Liang ChengShaobo Zhang
Feb 14, 2006·Cancer·Paulette Mhawech-FaucegliaJuerg Schwaller
Dec 5, 2008·Scandinavian Journal of Urology and Nephrology. Supplementum·Margaret A Knowles
Feb 11, 2015·Advances in Anatomic Pathology·James P Solomon, Donna E Hansel

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