Identification of long non-coding RNA CCAT1 as an oncogene in nasopharyngeal carcinoma

Oncology Letters
Yameng DongGuangyu Jin

Abstract

Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression levels of CCAT1 in NPC tissues and cell lines. The function of CCAT1 in the proliferation, migration, invasion and apoptosis of NPC cells was detected by MTT, cell scratch, Transwell, flow cytometry and caspase-3 ELISA assays, respectively. The results indicated that the expression levels of CCAT1 were significantly upregulated in NPC tissues compared with normal nasopharyngeal epithelial tissues. CCAT1 expression was also higher in SUNE-1 and C666-1 cells compared with NP69 cells. Furthermore, the knockdown of CCAT1 was indicated to inhibit growth, migration and invasion, and induce apoptosis in NPC cells. In conclusion, the present study is, to the best of our knowledge, the first to provide new findings that support an oncogenic role of CCAT1 in NPC. Further research is required to define the potential molecular m...Continue Reading

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