Identification of long noncoding RNA RP11-169F17.1 and RP11-669N7.2 as novel prognostic biomarkers of stomach adenocarcinoma based on integrated bioinformatics analysis

Epigenomics
Jue Yang, Hui Song

Abstract

Aim: We aim to identify differentially expressed long noncoding RNAs (lncRNAs) and explored their functional roles in stomach adenocarcinoma. Materials & methods: Based on public omics data, we identified disregulated lncRNAs and investigated their prognostic values and potential functions based on ceRNA hypothesis. Results: Among the 52 differentially expressed lncRNAs, upregulated RP11-169F17.1 and RP11-669N7.2 were significantly associated with both poor overall survival and disease-free survival. RP11-169F17.1 and RP11-669N7.2 strongly correlated with microRNAs in cancer, cell proliferation and differentiation. RP11-169F17.1 and RP11-669N7.2 closely related to Helicobacter pylori infection-induced gastritis, duodenal ulcer, gastric cancer and mucosa-associated lymphoid tissue lymphoma. Conclusion:RP11-169F17.1 and RP11-669N7.2 act as novel prognostic biomarkers of stomach adenocarcinoma and may also play an important role in H. pylori infection-induced gastric diseases.

References

May 17, 2007·Nature Reviews. Microbiology·Sebastian Suerbaum, Christine Josenhans
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jun 24, 2010·The Journal of Microbiology·Kyung-Mi KimSeung-Chul Baik
Oct 12, 2010·Clinical Microbiology Reviews·Lydia E WroblewskiKeith T Wilson
Mar 23, 2011·Molecular Cancer·Tony Bou KheirLennart Friis-Hansen
May 24, 2011·Biochemical and Biophysical Research Communications·Jesús Adrián López, Luis Marat Alvarez-Salas
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Feb 18, 2012·Nature·Mitchell Guttman, John L Rinn
May 17, 2012·PLoS Pathogens·Yoshan MoodleyMark Achtman
Nov 14, 2013·World Journal of Gastroenterology : WJG·Jae Yun LimJae Yong Cho
Sep 10, 2014·Oncology Letters·Li-Ping LiYa-Gang Zhao
Apr 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaoping LiJun Liu
Sep 20, 2015·Gastroenterology·Manuel Amieva, Richard M Peek
Dec 15, 2015·Cancer Discovery·Charles J SherrGeoffrey I Shapiro
Apr 14, 2016·Cancer Cell·Adam M Schmitt, Howard Y Chang
Oct 11, 2016·Biochemical and Biophysical Research Communications·Samir JanaArindam Bhattacharyya
Dec 26, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chaojing LuLixin Yang
Jan 12, 2017·Molecular Medicine Reports·Hongliang LiuKai Zhao
May 10, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Quan Wang, Jinhai Yu
Jul 7, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Kai YanYuanfang Zhu
Jul 14, 2017·Cancer Research·Arunoday BhanSubhrangsu S Mandal
Jul 22, 2017·Neoplasia : an International Journal for Oncology Research·Darshan S ChandrashekarSooryanarayana Varambally
Nov 7, 2017·Nucleic Acids Research·Jonathan CasperW James Kent
Nov 11, 2017·Nucleic Acids Research·Chih-Hung ChouHsien-Da Huang
Mar 22, 2018·The New England Journal of Medicine·Il Ju ChoiByung-Ho Nam
Oct 18, 2018·Nucleic Acids Research·Lina MaZhang Zhang

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Datasets Mentioned

BETA
GSE26595
GSE54397

Methods Mentioned

BETA
reverse transcription PCR

Software Mentioned

GEO2R
UALCAN
Metascape
AnnoLnc
Gene Expression Profiling Interactive Analysis ( GEPIA )
GEPIA
lncLocator
Cytoscape
LncBook
circlncRNAnet

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