Identification of low penetrance alleles for lung cancer: the GEnetic Lung CAncer Predisposition Study (GELCAPS).

BMC Cancer
Tim EisenGELCAPS Consortium

Abstract

Part of the inherited risk to lung cancer is likely to include common, low risk alleles. The identification of this class of susceptibility is contingent on association-based analyses. We established GEnetic Lung CAncer Predisposition Study (GELCAPS) to collect DNA and clinico-pathological data from a large series of cases and a series of spouse/partner controls, thereby generating a key resource for the identification of low risk alleles. GELCAPS was one of the first genetic epidemiological trials in the UK to be adopted by the National Cancer Research Network (NCRN) onto its portfolio with the participation of over 100 oncology departments specialising in the management of lung cancer. Samples from over 5,000 independent lung cancer cases and 2,000 controls have so far been assembled through GELCAPS. GELCAPS represents one of the largest datasets of its type in the world capable of informing on the contribution of low penetrance alleles to the development of lung cancer and the influence of genetic variation on outcome. In addition our experience in developing the GELCAPS serves to illustrate how large DNA biobanks for genetic analyses can be rapidly generated within the UK using the NCRN.

References

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Citations

May 28, 2009·European Journal of Human Genetics : EJHG·Emily WebbRichard S Houlston
Aug 21, 2013·Nature Genetics·Daniel ChubbHartmut Goldschmidt
Feb 4, 2010·Human Molecular Genetics·Dalemari Crowther-SwanepoelRichard S Houlston
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Apr 5, 2012·Journal of the National Cancer Institute·Nichola JohnsonOlivia Fletcher
Jun 2, 2014·Nature Genetics·Yufei WangChristopher I Amos
Dec 14, 2011·American Journal of Epidemiology·Steven J LubbeRichard S Houlston
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Oct 2, 2015·Nature Communications·Ben KinnersleyRichard S Houlston
Jul 22, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J LubbeRichard S Houlston
Jul 2, 2016·Nature Communications·Jonathan S MitchellRichard S Houlston
Oct 28, 2015·Nature Communications·Kevin LitchfieldClare Turnbull
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May 26, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·David C QianChristopher I Amos

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Methods Mentioned

BETA
for
genotyping
surgical resection

Software Mentioned

STATA
GELCAPS

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