PMID: 11921183Mar 29, 2002Paper

Identification of mammary carcinogens in rodent bioassays

Environmental and Molecular Mutagenesis
L Michelle Bennett, Barbara J Davis

Abstract

Results from chemical carcinogenesis studies in rodents are useful to identify substances in our environment that may contribute to cancer development. The National Toxicology Program (NTP) was established in 1978 to coordinate research and testing of potential human carcinogens and to publish the Report on Carcinogens, which lists human carcinogens. The results for over 500 chemicals tested in the NTP 2-year bioassays have been published in Technical Reports and include data for chemical, agent, or complex mixture exposures. The bioassays have identified 42 chemicals that induce tumors in the rodent mammary gland. The physical and chemical characteristics of the carcinogens vary, but epoxides (including chemicals metabolized to epoxides) and nitro-containing compounds are well represented. The 9th Report on Carcinogens, issued in 2000, lists 21 of the 42 chemicals as human carcinogens including benzene, ethylene oxide, 1,3-butadiene, isoprene, chloroprene, C.I. basic red 9, and C.I. acid red 114. Ethylene oxide was associated with increased breast cancer risk in an epidemiologic study, whereas other listed chemicals, for which human data are available, display different target organ specificity. Bioassays other than those cond...Continue Reading

References

Jan 1, 1974·Advances in Cancer Research·P Sims, P L Grover
Jan 1, 1984·Journal of Toxicology and Environmental Health·D L GreenmanM Norvell
Jan 1, 1995·Cancer Investigation·K S Kasprzak
Apr 1, 1995·International Journal of Epidemiology·S A NormanP D Stolley
Jun 7, 1996·Journal of Toxicology and Environmental Health·W C EastinJ H Yuan
May 1, 1997·Journal of Applied Toxicology : JAT·R D IrwinJ Roycroft
Sep 10, 1998·Nature Genetics·M RedstonK Offit
Nov 13, 1999·Molecular Carcinogenesis·L M Bennett
May 20, 2000·Journal of Mammary Gland Biology and Neoplasia·I H Russo, J Russo
Jun 8, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P M SiegelW J Muller
Nov 1, 2000·Breast Cancer Research : BCR·E SalaN Day
Nov 22, 2000·Journal of Toxicology and Environmental Health. Part a·J E French, M Saulnier
Jan 13, 2001·Oncogene·J N Hutchinson, W J Muller

❮ Previous
Next ❯

Citations

Jan 1, 1991·Free Radical Biology & Medicine·V V SubrahmanyamM T Smith
Sep 24, 2005·Journal of Toxicology and Environmental Health. Part a·Suzanne E FentonSherry G Selevan
Jun 27, 2003·Environmental Health Perspectives·Julia Green Brody, Ruthann A Rudel
Jun 4, 2004·Environmental Health Perspectives·Julia Green BrodyTheresa Kennedy
Jun 3, 2009·Archives of Physiology and Biochemistry·Juergen Sandow
Sep 19, 2006·Social Science & Medicine·Kami J SilkLeigh-Anne Goins
Jul 29, 2005·Toxicologic Pathology·Katsuhiko YoshizawaAbraham Nyska
Jan 27, 2018·Environmental Health Perspectives·Dale P SandlerUNKNOWN Sister Study Research Team
Dec 11, 2007·American Journal of Industrial Medicine·Bu-Tian JiWei Zheng
Jun 28, 2006·AAOHN Journal : Official Journal of the American Association of Occupational Health Nurses·Suzanne M Snedeker
Apr 4, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Grace E KisslingGary A Boorman
Mar 25, 2017·Molecular Medicine Reports·Chiara CostaConcettina Fenga
Oct 26, 2016·Molecular Medicine Reports·Luca FalzoneMassimo Libra
Jun 19, 2019·Environmental Monitoring and Assessment·J Kowalska, A Jeżewska
Jul 3, 2021·International Journal of Environmental Research and Public Health·Steffen MuellerShujun Liu
Feb 15, 2008·Pediatrics·Mari S GolubJorma Toppari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.