Dec 24, 2004

Identification of markers of the midface

Journal of Dental Research
S-G GongL Shum


Currently, much remains unknown of the genes that mediate the biological events during growth and fusion of the midfacial region, and the possible pathways through which these genes function. We took advantage of high-throughput microarray analysis to search for genes that may play a critical role in the growth and fusion of the midfacial region to become the primary palate. We identified several genes that were potentially expressed at different levels between tail somite (TS) 6-8 (pre-fusion) and TS 12-14 (fusion) in the 3 midfacial processes. Expression of 4 of these genes (Tbx14/15, Dickkopf-1, Fibroblast Growth Factor 8, and Keratin-18) was further verified by reverse-transcription/quantitative PCR and in situ hybridization at the 2 stages of midfacial development. With the identification of these genes, and possibly others, functional analyses can be conducted to improve our understanding of the mechanisms and pathways by which the midface forms.

  • References12
  • Citations13


  • References12
  • Citations13

Mentioned in this Paper

Biochemical Pathway
Microarray Analysis
Structure of Papilla Incisiva of Mouth
Dkk1 protein, mouse
FGF8 protein, human
Paracrine Protein Factors
Genetic Markers
Cytokeratin 18
Reverse Transcriptase Polymerase Chain Reaction
Fgf8 protein, mouse

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