PMID: 9434659Jan 22, 1998Paper

Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride

Journal of the American Geriatrics Society
I R KatzK D'Angelo

Abstract

To evaluate the cognitive effects of acute challenges with the antispasmodic agent oxybutynin hydrochloride in normal older volunteers and to compare these effects with those attributable to diphenhydramine, another commonly used medication with anticholinergic (muscarinic-blocking) activity. A double-blind, placebo-controlled cross-over study. Laboratory evaluations of community subjects. A convenience sample of 12 volunteers, average age 69.17 years. Baseline assessment was followed by randomized administration of a placebo, oxybutynin hydrochloride (5 and 10 mg), and diphenhydramine hydrochloride (50 mg) in test sessions separated by 1 week. Evaluation of cognitive performance with a 1-hour battery of pencil and paper, interviewer-administered, and computer-administered tests beginning 90 minutes after drug (or placebo) administration. Random regression analyses demonstrated that oxybutynin caused significant cognitive decrements on seven of 15 cognitive measures, and diphenhydramine caused decrements on five measures. The most sensitive measures for detecting the effects of oxybutynin hydrochloride were the Buschke Selective Reminding Test and Reaction Time. These findings demonstrate that oxybutynin can cause cognitive imp...Continue Reading

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