Abstract
Pulmonary sarcomatoid carcinomas (PSCs) constitutes a heterogeneous group of NSCLCs, which show poor prognosis even with aggressive surgical treatment and postoperative chemotherapy. The detection MET exon14 skipping (METex14 skipping) in PSCs suggests the targeted therapeutic opportunities with MET TKIs. We detected MET exon14 alterations using both targeted DNA- and RNA-based Next Generation Sequencing (NGS) and elucidated the driver mutation profile of 77 Chinese PSC patients. We also collected and analyzed the demographic features and clinical outcomes of patients harboring METex14 skipping mutation. METex14 skipping was detected in 20.8% of PSCs. A concordance of 96.1% was observed for DNA- and RNA-based NGS. 13 different genomic variants were revealed to induce METex14 skipping, including indels (N = 1) at splice acceptor sites, base substitutions (N = 4) and indels (N = 5) at splice donor sites, indels (N = 2) in the ∼20bp intronic noncoding region adjacent to the splice acceptor site, and indels (N = 1) in the exonic region. Patients harboring METex14 skipping tended to be older than others. In most cases, METex14 skipping were exclusive to other tumor driver alterations, however, we detected one case with METex14 skipp...Continue Reading
References
Dec 14, 2001·Molecular Cell·P PeschardM Park
Apr 14, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lorenzo Lo MuzioFrancesco Carinci
Mar 5, 2008·Cancer Research·David L ShattuckColleen Sweeney
May 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Isaac KindeBert Vogelstein
Jan 25, 2012·Nature Reviews. Cancer·Ermanno GherardiGeorge Vande Woude
Jun 29, 2012·Surgery·Sai YendamuriMary Reid
Sep 15, 2012·Genome Research·Jeong-Sun SeoYoung Tae Kim
Dec 21, 2013·Critical Reviews in Oncology/hematology·F GelsominoM Tiseo
Jan 7, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thibault VieiraMarie Wislez
Jul 30, 2014·American Journal of Clinical Oncology·Yongbin LinYing Liang
Aug 1, 2014·North American Journal of Medical Sciences·Imane OuzianeHassan Errihani
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Apr 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Saiama N WaqarJennifer Sehn
Jul 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xuewen LiuAlain C Borczuk
Jan 6, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark M AwadLynette M Sholl
Feb 6, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joanna H TongKa F To
May 26, 2016·Oncotarget·Difan ZhengHaiquan Chen
Jun 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexa B SchrockSai-Hong Ignatius Ou
Dec 28, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chien-Hung GowJin-Yuan Shih
Mar 14, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dohee KwonDoo Hyun Chung
Sep 25, 2017·Cancer Letters·Weihua LiJianming Ying
Citations
Jun 25, 2020·Thoracic Cancer·Saki ManabeKouzo Yamada
Dec 5, 2020·Oncogene·Xuewen LiuLikun Chen
Mar 2, 2021·Therapeutic Advances in Medical Oncology·Lingzhi HongXiuning Le