Identification of metabolites associated with prostate cancer risk: a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study.

BMC Medicine
Hanna E RöhnischAli A Moazzami

Abstract

Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age. In a case-control study nested in the Northern Sweden Health and Disease Study, pre-diagnostic concentrations of 148 plasma metabolites were determined using targeted mass spectrometry- and nuclear magnetic resonance-based metabolomics in 777 prostate cancer cases (follow-up ≥ 5 years) and 777 matched controls. Associations between prostate cancer risk and metabolite concentrations were investigated using conditional logistic regression conditioned on matching factors (body mass index, age and sample storage time). Corrections for multiple testing were performed using false discovery rate (20%) and Bonferroni. Metabolomics analyses generated new hypotheses, which were investigated by leveraging food frequency questionnaires (FFQs) and oral glucose tolerance tests performed at baseline. After correcting for multiple testing, two lysophosp...Continue Reading

References

Jul 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John D Storey, Robert Tibshirani
Jul 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pär StattinRudolf Kaaks
Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hong Gee Sim, Christopher W S Cheng
Jan 5, 2007·Nucleic Acids Research·David S WishartLori Querengesser
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Tanja StocksPär Stattin
Aug 19, 2008·Journal of Proteome Research·Jeremy K NicholsonPaul Elliott
Jan 19, 2010·Cancer Letters·Naghma KhanHasan Mukhtar
Mar 27, 2010·Global Health Action·Margareta NorbergLars Weinehall
Sep 1, 2011·Molecular Systems Biology·George NicholsonChris C Holmes
Mar 20, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Susanne KrugHannelore Daniel
Sep 27, 2012·Molecular Systems Biology·Rui Wang-SattlerThomas Illig
Oct 4, 2012·Prostate Cancer and Prostatic Diseases·D BansalP Tiwari
Aug 15, 2013·European Journal of Clinical Nutrition·A FloegelH Boeing
Oct 25, 2013·The American Journal of Clinical Nutrition·Paul John NestelPeter John Meikle
May 28, 2014·International Journal of Cancer. Journal International Du Cancer·Konstantinos K TsilidisTimothy J Key
Sep 26, 2014·Metabolomics : Official Journal of the Metabolomic Society·Alison M MondulDemetrius Albanes
Dec 21, 2014·The American Journal of Clinical Nutrition·Dagfinn AuneTeresa Norat
Apr 24, 2015·International Journal of Cancer. Journal International Du Cancer·Alison M MondulDemetrius Albanes
Dec 15, 2015·European Journal of Nutrition·Aahana ShresthaAli A Moazzami
Sep 29, 2018·International Journal of Biological Sciences·Xingjun HuangZhengquan Su
Apr 6, 2019·International Journal of Cancer. Journal International Du Cancer·Julie A SchmidtRuth C Travis

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Citations

May 1, 2021·International Journal of Molecular Sciences·Stefano SalcicciaMartina Maggi
Feb 26, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Xiaoshuang FengLorelei A Mucci

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

SAS
R Foundation for Statistical Computing Platform
RStudio
AQuA

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