Identification of methylene diphenyl diisocyanate thermal degradation products in a generation chamber by liquid chromatography coupled with tandem mass spectrometry

Journal of Occupational and Environmental Hygiene
Sébastien Gagné, Yves Cloutier

Abstract

Isocyanate thermal degradation characterization by liquid chromatography coupled with electrospray tandem mass spectrometry has been performed to elucidate the methylene diphenyl diisocyanate (MDI) thermal degradation structure emitted in a generation chamber using a temperature between 50°C and 180°C to produce MDI vapors. [M+H](+) ions containing an isocyanate functional group were studied by tandem mass spectrometry. The [M+H](+) ion analyses based on the combination of full scans and precursor ion scans were useful for identifying all structures. The compounds emitted were identified and validated as a mixture of compounds containing amine and isocyanate functions. Residual MDI, methylene diphenyl amino-isocyanate, and methylene diphenyl diamine were identified. Polymerized forms of these structures were also observed because amine and isocyanate chemical functions react rapidly to polymerize. These results must be used with special care by scientists establishing sensitization diagnostics and developing sampling devices using generation chambers as they must be related to MDI behavior in workplaces. Even if pure MDI is introduced in the generation chamber, several different compounds are generated when the MDI is heated at...Continue Reading

References

Jun 1, 1992·The Journal of Allergy and Clinical Immunology·O VandenplasJ L Malo
Jan 1, 1988·American Journal of Industrial Medicine·A W MuskD H Wegman
Apr 1, 1993·The Journal of Allergy and Clinical Immunology·O VandenplasJ L Malo
May 17, 2001·Journal of Environmental Monitoring : JEM·J MelinA Colmsjö
Aug 9, 2002·Applied Occupational and Environmental Hygiene·Jacques LesageHuu Van Tra
Oct 19, 2004·American Journal of Industrial Medicine·Dhimiter BelloCarrie A Redlich
Mar 31, 2005·Journal of Environmental Monitoring : JEM·Asa MarandGunnar Skarping
Jan 26, 2006·The Annals of Occupational Hygiene·Michel BoutinJacques Lesage

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