Identification of methylglyoxal as a major mutagen in wood and bamboo pyroligneous acids

Bioscience, Biotechnology, and Biochemistry
Aya OnodaH Nukaya


To identify the major mutagen in pyroligneous acid (PA), 10 wood and 10 bamboo pyroligneous acids were examined using the Ames test in Salmonella typhimurium strains TA100 and TA98. Subsequently, the mutagenic dicarbonyl compounds (DCs), glyoxal, methylglyoxal (MG), and diacetyl in PA were quantified using high-performance liquid chromatography, and the mutagenic contribution ratios for each DC were calculated relative to the mutagenicity of PA. Eighteen samples were positive for mutagens and showed the strongest mutagenicity in TA100 in the absence of S9 mix. MG had the highest mutagenic contribution ratio, and its presence was strongly correlated with the specific mutagenicity of PA. These data indicate that MG is the major mutagen in PA.


Oct 1, 1979·Mutation Research·M NagaoT Sugimura
Nov 1, 1975·Cancer Letters·T YahagiM Nagao
Sep 11, 1991·Mutation Research·A O AsitaH Matsushita
Mar 4, 1998·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·F IkegamiY Fujii
Nov 24, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K P PutnamD J Doolittle
May 23, 2001·Journal of Agricultural and Food Chemistry·M D GuillénM L Ibargoitia
Nov 9, 2006·Bioscience, Biotechnology, and Biochemistry·Yoshihiko AkakabeTakeshi Nyuugaku
Oct 12, 2007·Journal of Agricultural and Food Chemistry·Maria DagliaGabriella Gazzani
Oct 12, 2007·Bioscience, Biotechnology, and Biochemistry·Teruyuki UsuiFumitaka Hayase
Feb 6, 2010·Journal of Agricultural and Food Chemistry·Gema Arribas-Lorenzo, Francisco J Morales
Aug 2, 2012·Journal of Agricultural and Food Chemistry·Shinsuke MarumotoTakashi Watanabe

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