Identification of microRNA differentially expressed in three subtypes of non-small cell lung cancer and in silico functional analysis

Oncotarget
Yanjun HuYunxia Wang

Abstract

Emerging studies demonstrated that miRNAs played fundamental roles in lung cancer. In this study, we attempted to explore the clinical significance of the miRNA signature in different histological subtypes of non-small cell lung cancer (NSCLC). Three miRNome profiling datasets (GSE19945, GSE25508 and GSE51853) containing lung squamous cell carcinoma (SCC), lung adenocarcinoma (ADC) and large cell lung cancer (LCLC) samples were obtained for bioinformatics and survival analysis. Moreover, pathway enrichment and coexpression network were performed to explore underlying molecular mechanism. MicroRNA-375 (miR-375), miR-203 and miR-205 were identified as differentially expressed miRNAs (DEmiRNAs) which distinguished SCC from other NSCLC subtypes. Pathway enrichment analysis suggested that Hippo signaling pathway was combinatorically affected by above mentioned three miRNAs. Coexpression analysis of three miRNAs and the Hippo signaling pathway related genes were conducted based on another dataset, GSE51852. Four hub genes (TP63, RERE, TJP1 and YWHAE) were identified as the candidate targets of three miRNAs, and three of them (TP63, TJP1 and YWHAE) were validated to be downregulated by miR-203 and miR-375, respectively. Finally, survi...Continue Reading

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Citations

Oct 2, 2019·Current Molecular Medicine·Parisa NaeliHamed Mirzaei
Sep 18, 2018·Oncoimmunology·Adrien CostantiniEtienne Giroux Leprieur
Nov 26, 2020·International Journal of Molecular Sciences·Young-Ho Ahn, Yoon Ho Ko
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Oct 12, 2021·Experimental and Therapeutic Medicine·Feng LiuChenjun Huang
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yunxia AnXueyi Tang

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Datasets Mentioned

BETA
GSE25508
GSE51852
GSE19945
GSE16025
GSE51853

Methods Mentioned

BETA
transfection
transfections
PCR

Software Mentioned

DIANA
TargetScan
Cytoscape
Morpheus
STATA
SurvMicro
TargetScanHuman

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