Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System-Related Oligosaccharides

The Journal of Nutrition
Grégory PimentelGuy Vergères

Abstract

The use of biomarkers of food intake (BFIs) in blood and urine has shown great promise for assessing dietary intake and complementing traditional dietary assessment tools whose use is prone to misreporting. Untargeted LC-MS metabolomics was applied to identify candidate BFIs for assessing the intake of milk and cheese and to explore the metabolic response to the ingestion of these foods. A randomized controlled crossover study was conducted in healthy adults [5 women, 6 men; age: 23.6 ± 5.0 y; BMI (kg/m2): 22.1 ± 1.7].  After a single isocaloric intake of milk (600 mL), cheese (100 g), or soy-based drink (600 mL), serum and urine samples were collected postprandially up to 6 h and after fasting after 24 h. Untargeted metabolomics was conducted using LC-MS. Discriminant metabolites were selected in serum by multivariate statistical analysis, and their mass distribution and postprandial kinetics were compared. Serum metabolites discriminant for cheese intake had a significantly lower mass distribution than metabolites characterizing milk intake (P = 4.1 × 10-4). Candidate BFIs for milk or cheese included saccharides, a hydroxy acid, amino acids, amino acid derivatives, and dipeptides. Two serum oligosaccharides, blood group H dis...Continue Reading

References

Sep 1, 1979·Applied and Environmental Microbiology·F AragozziniR Gualandris
Dec 1, 1992·Journal of Internal Medicine·H O HeinF Gyntelberg
Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Aug 15, 2000·Annual Review of Nutrition·C KunzS Strobel
Mar 10, 2001·The British Journal of Nutrition·P K Gopal, H S Gill
Aug 9, 2001·The European Respiratory Journal·F RonchettiF Gloria-Bottini
Aug 14, 2001·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·S M Henry
Sep 24, 2004·Advances in Experimental Medicine and Biology·Jacques Le Pendu
Jun 1, 2007·Journal of Clinical Microbiology·Elin KindbergLennart Svensson
Aug 9, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sheila BinghamKay Tee Khaw
Aug 19, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Emmanuel CurisLuc Cynober
Apr 29, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pascal CrennLuc Cynober
Oct 4, 2008·Journal of Dairy Science·N TaoC B Lebrilla
Jul 18, 2009·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·UNKNOWN Blue Green Alliance
Aug 25, 2010·American Journal of Respiratory and Critical Care Medicine·Anh L InnesJohn V Fahy
Jul 28, 2011·BMJ : British Medical Journal·Machteld HuberHenk Smid
Jun 6, 2012·The Journal of Infection·Dennis NurjadiPhilipp Zanger
Apr 12, 2013·The American Journal of Clinical Nutrition·Rachel BoutrouJoëlle Leonil
Sep 1, 2007·Metabolomics : Official Journal of the Metabolomic Society·Lloyd W SumnerMark R Viant
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Purna C KashyapJustin L Sonnenburg
Nov 28, 2013·The Journal of Infectious Diseases·Berthe-Marie Imbert-MarcilleJacques Le Pendu
Apr 25, 2014·The American Journal of Clinical Nutrition·Augustin ScalbertDavid S Wishart
Nov 23, 2015·Cell·David ZeeviEran Segal
Nov 20, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·K IharaUNKNOWN Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
Nov 20, 2016·Revista brasileira de hematologia e hemoterapia·Luiz Carlos de Mattos
Dec 30, 2016·The American Journal of Clinical Nutrition·Mary C PlaydonRachael Stolzenberg-Solomon
May 31, 2017·Molecular Nutrition & Food Research·Helena GibbonsLorraine Brennan
Oct 5, 2017·Genes & Nutrition·Lars O DragstedEdith J M Feskens
Nov 16, 2017·The Proceedings of the Nutrition Society·Elske M Brouwer-BrolsmaEdith J M Feskens

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Methods Mentioned

BETA
NMR

Clinical Trials Mentioned

NCT02705560

Software Mentioned

PLS
DA
R Foundation for Statistical Computing
FoodBAll
R pheatmap package
MESS R package
R
Progenesis QI
OPLS
R package

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