Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats

Alcoholism, Clinical and Experimental Research
Giancarlo ColomboMauro A M Carai

Abstract

Previous work found that extracts from the roots of Salvia miltiorrhiza, a Chinese medicinal herb, reduced alcohol intake in selectively bred Sardinian alcohol-preferring (sP) rats. The present study was designed to evaluate whether miltirone, one of the possible active constituents of S. miltiorrhiza, might be responsible for the reducing effect of the extracts on alcohol intake. An initial experiment assessed the effect of 100 mg/kg (intragastric, i.g.) of 4 extracts of S. miltiorrhiza, differing in miltirone content (0, 2, 3, and 7%, respectively), on alcohol intake in alcohol-experienced sP rats exposed to the 2-bottle "alcohol (10%, volume in volume) versus water" choice regimen. Subsequently, the effect of pure miltirone (2.5-10 mg/kg, i.g., i.e., a dose range comparable to its content in the effective doses of the active extracts) on acquisition and maintenance of alcohol-drinking behavior was evaluated in alcohol-naive and alcohol-experienced sP rats exposed to the 2-bottle choice regimen. The effect of miltirone (10 mg/kg, i.g.) on blood alcohol levels was assessed after the i.g. and intraperitoneal (i.p.) administration of alcohol. Finally, the effect of miltirone (30-100 mg/kg, i.g.) on the severity of alcohol withdr...Continue Reading

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Citations

Jan 12, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fang WangHua-Bin Li
Jan 20, 2009·The American Journal of Drug and Alcohol Abuse·Lin LuThomas R Kosten
Feb 14, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ludovico AbenavoliGiovanni Addolorato
Mar 17, 2007·International Journal of Cardiology·Tsung O Cheng
Oct 30, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xuelin ZhouJohn H K Yeung
Dec 31, 2017·Journal of the Chinese Medical Association : JCMA·Carla LobinaAntonella Riva
May 26, 2018·Acta Pharmacologica Sinica·Wei SongZhang-Yin Ming
Mar 3, 2020·Frontiers in Pharmacology·Laxman SinghAtanas G Atanasov
Jun 3, 2015·Journal of Natural Products·Ching-Fen Wu, Thomas Efferth

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