PMID: 7537510Jan 1, 1995Paper

Identification of MIP-1 alpha/LD78 as a monocyte chemoattractant released by the HTLV-I-transformed cell line MT4

AIDS Research and Human Retroviruses
R BertiniJ Van Damme

Abstract

It is known that the HTLV-I-transformed cell line MT4 releases chemotactic activity for monocytes spontaneously. The MT4 monocyte chemoattractant was purified to homogeneity and sequencing of 25 amino acids revealed identity with the C-C chemokine macrophage inflammatory protein-1 alpha (MIP-1 alpha/LD78). An anti-MIP-1 alpha/LD78 rabbit antiserum substantially inhibited chemotaxis of the MT4 chemoattractant. MT4 cells constitutively expressed MIP-1 alpha/LD78 but not the C-C chemokines MCP-1, RANTES, and MIP-1 beta/Act2 and the C-X-C chemokines IL-8, gro alpha, and gro beta. MT4-derived MIP-1 alpha/LD78 was active on monocytes but was a weak chemoattractant for polymorphonuclear leukocytes. Thus, MIP-1 alpha/LD78 is a major monocyte chemoattractant released by HTLV-I-transformed T cells. Expression of MIP-1 alpha/LD78, a leukocyte chemotactic and myelosuppressive molecule, may play an important role in the manifestations of HTLV-I-related diseases.

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Citations

Jun 1, 1997·Blood Reviews·O C FerreiraJ D Rosenblatt
Aug 17, 1999·The Journal of Clinical Investigation·P MentenJ Van Damme
Jul 23, 2013·PLoS Genetics·Marianna OrlovaErwin Schurr
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yosuke OkadaYoshiya Tanaka
Jul 18, 2006·Biochemical Pharmacology·Anja MuellerPhilip G Strange
Apr 22, 2004·Nature Reviews. Microbiology·Anthony L DeVico, Robert C Gallo
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia L GregoryMichael J Hickey
Apr 2, 2020·Frontiers in Microbiology·Razieh ZargariHoushang Rafatpanah

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