Identification of mood stabilizer-regulated genes by differential-display PCR

The International Journal of Neuropsychopharmacology
J F WangL T Young

Abstract

An increasing body of evidence demonstrates that lithium and valproate have a regulatory effect on signal transduction pathways. Alteration of signalling molecules triggers changes in gene expression which are thought to contribute to the therapeutic effects of these drugs on bipolar disorder. Differential-display PCR was used to identify genes in rat cerebral cortex that are regulated by chronic treatment with lithium and valproate. One novel lithium-regulated gene was identified and was characterized and studied further with 5'-RACE-PCR and library screening. We also found that valproate regulated the expression of the 78-kDa glucose-regulated protein (GRP78). Chronic treatment with valproate has also been found to increase gene transcription, mRNA and protein levels of GRP78. These results suggest novel targets for lithium and valproate that may be relevant to their mechanism of action. The data further our understanding of the mechanism of the action of mood stabilizers, and help identify new targets for genetic studies and therapeutic strategies in bipolar disorder.

Citations

Jun 11, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Martin AldaL Trevor Young
Nov 21, 2002·Pharmacology & Therapeutics·Nadia Gurvich, Peter S Klein
Jun 9, 2005·Molecular Psychiatry·E HattoriE S Gershon
Mar 27, 2003·The Australian and New Zealand Journal of Psychiatry·Ramesh K GuptaGraham D Burrows
Dec 1, 2003·Acta Neuropsychiatrica·B Corbella, E Vieta
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Nov 15, 2001·Current Psychiatry Reports·S L Dubovsky
Oct 2, 2003·Expert Opinion on Investigational Drugs·Michael Berk, Seetal Dodd
Jan 30, 2009·Journal of Cellular and Molecular Medicine·M W LawlessS G Gray
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Roberto B Sassi, Jair C Soares
Sep 2, 2003·Nature Genetics·Chihiro KakiuchiTadafumi Kato
Sep 5, 2002·Medicinal Research Reviews·Roman A Blaheta, Jindrich Cinatl
Apr 3, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Yarema Bezchlibnyk, L Trevor Young

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.