Identification of mouse genes with highly specific expression patterns in differentiated intestinal epithelium

Gastroenterology
Natalia SchröderAchim Gossler

Abstract

Few genes that regulate intestinal epithelium development, homeostasis, or function are known. We reasoned that potential candidate regulators of these processes could be identified based on their activation during intestinal epithelium development and their subsequent specific and restricted expression. Genes were identified by differential display and microarray analyses, further selected according to sequence and UniGene expression profiles, and analyzed by RNA in situ hybridization of mouse fetal and adult intestines and in intestinal polyp tissue. Five genes with unknown physiological function predominantly or exclusively expressed in the intestinal epithelium were identified. Their expression is activated at distinct times during intestinal development and maturation and is maintained in highly specific, spatially distinct patterns in the adult intestinal epithelium. Two of the genes were up-regulated in intestinal tumors, 1 was down-regulated, and 2 were apparently unaltered. Based on sequence and expression, the identified genes represent good candidates for regulators of intestinal epithelium integrity or function. Their expression patterns suggest a morphologically not obvious molecular regionalization of the intestin...Continue Reading

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Citations

Dec 24, 2010·American Journal of Physiology. Endocrinology and Metabolism·Jay V PatankarSanja Levak-Frank
Jun 15, 2011·BMC Genomics·Ulrich C KlostermeierPhilip Rosenstiel
Jul 19, 2012·World Journal of Gastroenterology : WJG·Alan B R ThomsonHugh Freeman
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Apr 3, 2019·International Journal of Molecular Sciences·Lucie JaneckovaVladimir Korinek
Apr 24, 2009·Developmental Cell·Nan GaoKlaus H Kaestner

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