Identification of mouse submaxillary gland protein in mouse saliva and its binding to mouse oral bacteria

Archives of Oral Biology
B LeeYvonne Myal

Abstract

The mouse submaxillary gland protein (mSMGP) is highly expressed in the submandibular gland of the adult mouse and rat. It shares 51% identity at the amino-acid level with a human protein, the prolactin-inducible protein (PIP)/gross cystic disease fluid protein 15 (GCDFP-15), which has been found in saliva, tears, sweat, seminal plasma, submucosal glands of the lung and amniotic fluid. More recently, the human PIP has been reported to bind to bacterial strains normally found in the mouth, ear canal and human skin. Sequence analysis of mSMGP/PIP earlier identified the presence of a signal peptide, suggesting that it is a secreted protein. Here, by Western blotting, mSMGP/PIP has been identified in mouse saliva. To investigate further the role of this secreted protein, its ability to bind specifically to oral bacteria was examined; the hypothesis was that mSMGP/PIP is involved in non-immune host defence by binding to bacteria. Several bacterial strains, found to belong to the genera Streptococcus, Aerococcus, Pseudomonas, Staphylococcus, Sphingomonas, Vibrio and Aeromonas, were isolated from the mouse oral cavity. Following incubation of these bacteria with (35)S-labeled, in vitro-translated mSMGP/PIP, the protein was found to bi...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 1, 1992·Infection and Immunity·A J LigtenbergA V Amerongen
Sep 3, 1990·Biochimica Et Biophysica Acta·K Akiyama, H Kimura
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J P Tam
Aug 1, 1986·Canadian Journal of Microbiology·L TrudelM C Lavoie
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Barka
Dec 1, 1993·Journal of Dental Research·L C SchenkelsA Van Nieuw Amerongen
Jul 1, 1996·The Journal of Investigative Dermatology·T JinquanK Thestrup-Pedersen
Aug 7, 1998·The International Journal of Biochemistry & Cell Biology·P H WatsonL C Murphy
Aug 26, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L MirelsH J Branin
Dec 14, 1999·The American Journal of Pathology·S Al-HaddadP H Watson
Oct 12, 2000·Clinical Microbiology Reviews·X LiI Olsen
Apr 1, 1956·Journal of Dental Research·M A BENARDEH R HUNT

❮ Previous
Next ❯

Citations

Aug 2, 2003·Molecular and Cellular Endocrinology·Beverley LeeYvonne Myal
Aug 19, 2011·Journal of Agricultural and Food Chemistry·Katharina LorenzThomas Hofmann
Oct 17, 2009·Oral Microbiology and Immunology·A NistorY Myal
Aug 27, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·É CsőszJ Tőzsér
Aug 2, 2019·Cancers·Chidalu A EdechiYvonne Myal
Feb 9, 2012·Molecular BioSystems·Michael B BorderSompop Bencharit
Mar 12, 2009·Journal of Proteome Research·Alison WaldramJeremy K Nicholson
Aug 12, 2021·Canadian Journal of Physiology and Pharmacology·Lucas E L TerceiroYvonne Myal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.