PMID: 38880Aug 10, 1979

Identification of MSH release-inhibiting elements in the neurointermediate lobe of the rat

Brain Research
F J TildersA H Mulder


Neurointermediate lobes of rats comprise elements which, when excited in vitro, bring about an inhibition of the release of melanocyte stimulating hormone (MSH). Superfusion of neurointermediate lobes of intact donor rats with medium containing 45 mM K+ induced a stimulation of the release of oxytocin, arginine-vasopressin and dopamine (DA) and inhibited the release of MSH. Fluorescence histochemical observations and the results of release studies indicate that electrothermic lesions in the mediobasal hypothalamus induced a more rapid degeneration of dopaminergic than of peptidergic terminals in the neurointermediate lobe. Dopaminergic nerve terminals and the stimulated release of DA had vanished completely on the second day after these lesions, which coincided with the disappearance of K+-induced inhibition of MSH release. Frontal hypothalamic deafferentations resulted in disappearance of peptidergic nerve terminals as evidenced by the development of diabetes insipidus and the strong decline of depolarization-induced release of oxytocin and vasopressin from neurointermediate lobes in vitro. In contrast, the dopaminergic plexus was left intact, as was the K+-induced stimulation of DA release and inhibition of MSH release. We co...Continue Reading


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May 1, 1990·The Anatomical Record·L C SalandS Desai
Feb 8, 1986·The Journal of Comparative Neurology·P H LuppiM Jouvet


Jan 1, 1976·Journal of Clinical Pathology. Supplement (Association of Clinical Pathologists)·P M Daniel
Oct 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F J TildersP G Smelik
Jun 18, 1971·Biochemical and Biophysical Research Communications·R M NairA V Schally
Oct 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C Sachs, G Jonsson
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M E CelisR Walter
Jan 1, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·D S Vincent, T C Kumar
Jun 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·S TaleisnikJ De Olmos

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