PMID: 8605113Dec 1, 1995Paper

Identification of multiple chromosome 12 abnormalities in human testicular germ cell tumors by two-color fluorescence in situ hybridization (FISH)

Genes, Chromosomes & Cancer
T A SmolarekN A Heerema

Abstract

The distribution of segments of the short and long arms of chromosome 12 was distinguished by two-color fluorescence in situ hybridization (FISH) in 27 cytogenetically abnormal testicular germ cell tumors (TGCTs). A 12p-specific probe was developed by chromosomal microdissection and sequence-independent polymerase chain reaction (PCR) amplification and was combined with a commercially available whole-chromosome 12 painting probe. The TGCTs included both i(12p)-positive and i(12p)-negative primary tumors and lymph node metastases from patients in clinical stage I or stage II who were not previously treated with chemotherapy. Rearrangements of the short arm of chromosome 12 and overrepresentation of 12p DNA sequences were found in all cases. In addition, cryptic rearrangements of 12p were found in 39% (7/18) of the i(12p)-positive tumors and in 78% (7/9) of the i(12p)-negative tumors. Only 7% (2/27) of all tumors had cryptic rearrangements of 12q.

References

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Citations

Aug 10, 1999·Genes, Chromosomes & Cancer·W V YotovE Levy
May 30, 2002·Cancer Genetics and Cytogenetics·Barbara Pienkowska-GrelaUrszula Bregula
Oct 29, 1998·Molecular Medicine Today·S G Lutzker, N J Barnard
May 29, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kevin M KernekLiang Cheng
Apr 29, 1998·Cancer Investigation·N A Heerema
Jan 31, 2016·Human Pathology·Kristine M CornejoZhong Jiang
Sep 27, 2018·The American Journal of Surgical Pathology·Chia-Sui KaoThomas M Ulbright
Sep 4, 2019·The American Journal of Surgical Pathology·Muhammad T IdreesJonathan I Epstein

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