PMID: 9159409Jan 1, 1997Paper

Identification of murine T cells reactive with the bacterial superantigen Yersinia pseudotuberculosis-derived mitogen (YPM) and factors involved in YPM-induced toxicity in mice

Microbiology and Immunology
T Miyoshi-AkiyamaT Uchiyama

Abstract

We previously reported that Yersinia pseudotuberculosis-derived mitogen (YPM) acts as a superantigen to human T cells. In this study, we assessed the superantigenicity and toxicity of YPM using murine experimental models. YPM activated T cells to produce interleukin-2 in a major histocompatibility complex class II molecule-dependent manner. The T-cell blasts induced by YPM expressed T-cell receptor (TCR) beta-chain variable region (Vbeta)7, Vbeta8.1, Vbeta8.2 and Vbeta8.3. The injection of YPM into mice pre-sensitized with D-galactosamine induced lethal shock. This shock was blocked by the injection of monoclonal antibodies (mAbs) to CD4, TCR Vbeta7 plus Vbeta8, tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), but not by injection to CD8 or unrelated Vbeta. These results indicate that YPM-induced shock requires the presence of CD4+ T cells bearing TCR Vbeta7 and Vbeta8, and that endogenous TNF-alpha and IFN-gamma mediate the lethal effects.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Feb 1, 1992·The Journal of Experimental Medicine·J W KapplerP Marrack
Jan 1, 1992·Immunogenetics·K TomonariH Hengartner
Feb 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W J GaughanM Yudis
Jul 1, 1987·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·K SanbeM Ohtawara

❮ Previous
Next ❯

Citations

Mar 9, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hirotsugu KanoJun Abe
Oct 12, 2001·Toxicon : Official Journal of the International Society on Toxinology·H Müller-AloufJ E Alouf
Jul 27, 2002·Journal of Bacteriology·Christophe CarnoyMichel Simonet
Sep 2, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Minh Hung DangJunji Yagi
Mar 8, 2008·PloS One·Zoran Popmihajlov, Kendall A Smith
May 2, 2003·Journal of Medical Microbiology·V A FeodorovaZ L Devdariani
Jan 8, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elisa Monzón-CasanovaThomas Herrmann
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luqiu ChenTakehiko Uchiyama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.