Identification of murine type I keratin 9 (73 kDa) and its immunolocalization in neonatal and adult mouse foot sole epidermis.

Experimental Cell Research
J SchweizerH Winter

Abstract

The foot sole epidermis of the fore and hind feet of the adult mouse contains an acidic (type I) mRNA-encoded 73-kDa keratin polypeptide which cannot be detected in any other skin site of the mouse integument. Western blot analysis using an antibody specific for the 64-kDa keratin 9 of human and bovine callus-forming epidermis [A. C. Knapp et al. (1986) J. Cell Biol. 103, 657-667] demonstrates that the 73-kDa keratin represents the murine analog of keratin 9 of man and cow. Concomitant investigations in two related rodent species indicate that the size of this keratin varies more among species than that of any other orthologous keratin. Histological examination of adult mouse foot sole skin reveals an extremely thick and undulated epidermis covering the apical portion of the six footpads, whereas the epidermal-dermal junction of the lateral walls of these nodular protuberances as well as that of the remainder of the foot sole skin is essentially flat. If sections of adult foot sole skin are investigated by indirect immunofluorescence with the keratin 9-specific antibody, intense cytoplasmic staining is restricted to the apical rete pegs of the footpad epidermis in which virtually all suprabasal cells express keratin 9. However,...Continue Reading

References

Sep 1, 1985·Cell·P M SteinertD R Roop
Jan 1, 1987·Journal of Molecular Evolution·E M KlingeM Blumenberg
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L D JohnsonP M Steinert
Jan 1, 1988·Annual Review of Biochemistry·P M Steinert, D R Roop
Apr 1, 1985·Neurology·F Schiller
May 1, 1980·Carcinogenesis·H WinterK Goerttler
Dec 1, 1981·Experimental Cell Research·S P Banks-SchlegelG S Pinkus
Oct 1, 1981·The Biochemical Journal·P E Bowden, W J Cunliffe
Jan 1, 1982·Differentiation; Research in Biological Diversity·J Schweizer, H Winter
Nov 1, 1982·The Journal of Cell Biology·J Woodcock-MitchellT T Sun
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D R RoopS H Yuspa
Jan 1, 1984·Differentiation; Research in Biological Diversity·J SchweizerI C Mackenzie
Jun 1, 1980·The Biochemical Journal·P M SteinertM L Wantz

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Citations

May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·A RamírezJ L Jorcano
May 1, 2004·Cells, Tissues, Organs·Bryon MahlerJohn Foley
Aug 22, 2013·The Journal of Investigative Dermatology·Dun Jack FuDeena M Leslie Pedrioli
Jul 15, 2005·Molecular Reproduction and Development·Eugene RivkinAbraham L Kierszenbaum
Feb 1, 1997·Differentiation; Research in Biological Diversity·M A RogersJ Schweizer
Jan 25, 2007·Differentiation; Research in Biological Diversity·Jennifer EastwoodJohn Foley
Nov 10, 2000·Developmental Biology·K MochidaA L Kierszenbaum
Jul 3, 1999·The Journal of Biological Chemistry·L LangbeinJ Schweizer
Dec 24, 2018·The Journal of Investigative Dermatology·Chung-Ping LiaoLu Q Le
Aug 19, 2018·The Journal of Investigative Dermatology·Rongying ZhouLuis A Garza
Feb 1, 1994·The Journal of Investigative Dermatology·F HerzogJ Schweizer

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