Nov 1, 1975

Identification of NADPH-thioredoxin reductase system in Euglena gracillis

Proceedings of the National Academy of Sciences of the United States of America
S MunavalliF D Hamilton


Euglena gracilis contains a protein system which can utilize the reducing power of NADPH in the ribonucleotide reductase-catalyzed reduction of CTP. The proteins required for this reaction are a flavoprotien with a molecular weight of approximately 185,000 which is functionally similar to thioredoxin reductase (NADPH), EC, and another protein (Protein I) whose function in the reaction is unknown. This new protein does not appear to contain a prosthetic group and has a molecular weight of approximately 240,000. In addition, the ribonucleotide reductase active in the Euglena NADPH-thioredoxin reductase system is more complex than the protein reported in a previous publication [(1974) j. Biol. Chem. 249, 4428-4434]. The enzyme preparation described in this report contains four different types of polypeptide chains which may complex to form the active enzyme.

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Mentioned in this Paper

Thioredoxin Reductase (NADPH)
Synapsin I
Ribonucleotide Reductase
Staphylococcal Protein A
Enzyme agent
Protein Conformation
Euglena gracilis
NADH, NADPH Oxidoreductases

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