PMID: 9184646Jun 1, 1997Paper

Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with major histocompatibility complex class I molecules

Journal of Neuroimmunology
Y VannesteV Geenen

Abstract

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain +/-5 ng immunoreactive (ir) NT/10(6) cells, of which 5% is associated with plasma cell membranes. HPLC analysis of NT-ir present in human TEC showed a major peak of NT-ir corresponding to NT1-13. NT-ir was not detected in the supernatant of human TEC cultures. Using an affinity column prepared with a anti-MHC class I monoclonal antibody, NT-ir-related peptides were retained on the column and eluted together with MHC class I-related proteins. According to the elution time on HPLC of these peptides, they correspond to intact NT1-13, as well as to smaller fragments of NT1-13.

References

Jan 1, 1992·Developmental Immunology·F R RobertV Geenen
Jan 1, 1992·Annals of the New York Academy of Sciences·R E CarrawayG Spaulding
Apr 1, 1991·Molecular and Cellular Endocrinology·V GeenenP Franchimont
Jan 1, 1987·International Archives of Allergy and Applied Immunology·O Söder, P M Hellström
Aug 1, 1994·Immunology Today·P G Ashton-Rickardt, S Tonegawa
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Apr 1, 1993·Current Opinion in Immunology·A M Kruisbeek

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Citations

Jun 8, 2011·Clinical & Developmental Immunology·Aziz Alami Chentoufi, Vincent Geenen
Jun 10, 2003·Annals of the New York Academy of Sciences·Vincent Geenen, Fabienne Brilot
Dec 1, 2001·Expert Opinion on Biological Therapy·B Bodey
Mar 21, 2002·Expert Opinion on Therapeutic Targets·Bela Bodey
Jun 22, 2012·Diabetes Research and Clinical Practice·Vincent Geenen
Apr 23, 2019·Annals of the New York Academy of Sciences·Vincent GeenenHenri Martens
Mar 29, 2014·International Journal of Molecular Medicine·Fiorenzo MigniniCarlo Cavallotti
May 21, 1999·Journal of Neuroendocrinology·O KechaR Winkler
Sep 1, 2004·Experimental Biology and Medicine·Guido RindiAndrew B Leiter
Mar 28, 2001·Annals of the New York Academy of Sciences·V GeenenO Kecha
Jan 9, 2021·Seminars in Immunopathology·Vincent Geenen

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