Identification of new markers discriminating between myeloid and lymphoid acute leukemia

Houda HaouasAïcha Hafsia


The heterogeneity of acute myeloid leukemia (AML) with respect to biology and clinical course resides in the fact that patients belonging to the same group show marked differences in their response to chemotherapy, necessitating a refinement of AML classification. In order to define molecular markers for AML, we performed microarray analysis on peripheral blood cells from two M5 AML patients, and selected four differentially expressed genes to validate their expression by real-time quantitative PCR (RT-PCR). We have shown that two downregulated genes in AML, those encoding guanine nucleotide-binding protein gamma11 (GNG11) and amphiregulin (AREG), are also downregulated in B-lineage acute lymphoblastic leukemia (B-ALL) and T-lineage acute lymphoblastic leukemia (T-ALL) patients. A second gene, that encoding ceruloplasmin (CP), is upregulated in AML but not in B-ALL and T-ALL. The level of expression of these genes varies from one patient to another. Since the number of patients studied is limited, further studies are needed with a larger series of patients to evaluate the potential utility of GNG11, AREG and CP as molecular markers for AML subtype classification. Our study is the first to analyze these genes in AML, B-ALL, T-AL...Continue Reading


Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Sep 20, 2002·Blood·James W VardimanRichard D Brunning
Jan 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan FröhlingKonstanze Döhner
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Apr 16, 2004·The New England Journal of Medicine·Lars BullingerJonathan R Pollack
Apr 16, 2004·The New England Journal of Medicine·Peter J M ValkRuud Delwel
Apr 16, 2004·The New England Journal of Medicine·David Grimwade, Torsten Haferlach
Dec 21, 2004·Nucleic Acids Research·H ParkinsonA Brazma
Apr 23, 2005·Nature Methods·Jennie E LarkinJohn Quackenbush
Apr 23, 2005·Nature Methods·Rafael A IrizarryWayne Yu
May 10, 2005·Blood·Torsten HaferlachClaudia Schoch
Jan 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudia D BaldusGerhard Ehninger
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciUNKNOWN Cancer and Leukemia Group B Study

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Jun 15, 2011·Hematology·Marco Wiltgen, Gernot P Tilz
Dec 24, 2013·BioMed Research International·Javier Fernández-TorresAlberto López-Reyes
Apr 30, 2019·Current Medicinal Chemistry·Frode SelheimAnna M Aragay
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