Identification of new markers discriminating between myeloid and lymphoid acute leukemia

Hematology
Houda HaouasAïcha Hafsia

Abstract

The heterogeneity of acute myeloid leukemia (AML) with respect to biology and clinical course resides in the fact that patients belonging to the same group show marked differences in their response to chemotherapy, necessitating a refinement of AML classification. In order to define molecular markers for AML, we performed microarray analysis on peripheral blood cells from two M5 AML patients, and selected four differentially expressed genes to validate their expression by real-time quantitative PCR (RT-PCR). We have shown that two downregulated genes in AML, those encoding guanine nucleotide-binding protein gamma11 (GNG11) and amphiregulin (AREG), are also downregulated in B-lineage acute lymphoblastic leukemia (B-ALL) and T-lineage acute lymphoblastic leukemia (T-ALL) patients. A second gene, that encoding ceruloplasmin (CP), is upregulated in AML but not in B-ALL and T-ALL. The level of expression of these genes varies from one patient to another. Since the number of patients studied is limited, further studies are needed with a larger series of patients to evaluate the potential utility of GNG11, AREG and CP as molecular markers for AML subtype classification. Our study is the first to analyze these genes in AML, B-ALL, T-AL...Continue Reading

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Citations

Jun 18, 2011·Expert Review of Proteomics·Juan Casado-VelaJuan Carlos Lacal
Jun 15, 2011·Hematology·Marco Wiltgen, Gernot P Tilz
Dec 24, 2013·BioMed Research International·Javier Fernández-TorresAlberto López-Reyes
Apr 30, 2019·Current Medicinal Chemistry·Frode SelheimAnna M Aragay
Aug 15, 2021·Annals of Hematology·Julian BaumeisterDeniz Gezer
Oct 14, 2011·Current Opinion in Oncology

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