Identification of new prognostic factors of pulmonary hypertension

Circulation Journal : Official Journal of the Japanese Circulation Society
Yutaka MiuraHiroaki Shimokawa

Abstract

Pulmonary hypertension (PH) still remains a serious disease, for which the plasma level of brain natriuretic peptide (BNP) and hemodynamic variables (eg, cardiac index: CI) are established prognostic factors. The aim of the present study was to identify new additional prognostic factors of the disorder to improve the management of PH. The study cohort comprised 136 consecutive PH patients admitted to hospital from 1974 to 2008, all of whom were closely followed every 6-12 months. During the follow-up period of 53.5+/-4.5 [SEM] months, 47 patients died of cardiopulmonary causes. The patients who were initially treated with monotherapy showed improved pulmonary hemodynamics when subsequently treated with combination therapy. Multivariate analysis showed that BNP and CI were significant and independent prognostic factors in all PH patients. However, in PH patients with low CI at diagnosis, only CI improvement by PH therapy was a significant and independent prognostic factor. Indeed, the patients with low CI at diagnosis (CI <2.5) followed by subsequent normalization in response to therapy (CI > or =2.5) showed a significantly better survival compared with those without such normalization. CI normalization in response to treatment ...Continue Reading

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Citations

Aug 30, 2012·European Heart Journal·Tatsuo AokiHiroaki Shimokawa
Jul 13, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro Fukumoto, Hiroaki Shimokawa
Aug 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihiro Fukumoto
Aug 30, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Saori Miyamichi-YamamotoHiroaki Shimokawa
Dec 22, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichiro SugimuraHiroaki Shimokawa
Feb 9, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Shunsuke TatebeHiroaki Shimokawa
May 9, 2014·Experimental Lung Research·Yuanyuan WuManxiang Li
Dec 10, 2013·The American Journal of Cardiology·Stefania FarinaPiergiuseppe Agostoni
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Apr 4, 2015·The Canadian Journal of Cardiology·Sadiya S Khan, Jonathan D Rich
Apr 27, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Kimio Satoh, Hiroaki Shimokawa
Oct 11, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Kimio Satoh
Jul 7, 2019·Biochemical and Biophysical Research Communications·Xin YanManxiang Li
Jun 10, 2011·Current Opinion in Cardiology

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