PMID: 11344996May 10, 2001Paper

Identification of new therapies for leiomyomas: what in vitro studies can tell us

Clinical Obstetrics and Gynecology
R A Nowak

Abstract

Leiomyomas are a significant problem in women's health. An understanding of the biology of these tumors and how their growth is regulated is emerging from in vitro studies using tissue specimens and cultured cells. These studies have clarified how the ovarian steroid hormones regulate growth of uterine SMCs and how the ovarian steroid ligand-receptor system has been altered in leiomyomas. Such information will allow investigators to identify steroid hormone antagonists and steroid hormone receptor modulators that may be useful for treatment of leiomyomas. We are now also developing a much better understanding of the growth factors that are produced by SMCs of leiomyoma tumors. These growth factors not only regulate the proliferation, apoptosis, and extra-cellular matrix production of the SMCs but also regulate proliferation and migration of vascular endothelial cells. Targeting these growth factors and their receptors can reduce leiomyoma growth through two different mechanisms. One targets the SMCs and the other targets the vascular system that supports the growth of the tumor. Another important lesson that can be learned from reading the scientific literature is that there are striking similarities between the biology of uter...Continue Reading

References

Oct 1, 1992·The Journal of Clinical Investigation·S NikolL Weir
May 28, 1992·The New England Journal of Medicine·R A EzekowitzJ Folkman
Oct 1, 1990·Molecular Reproduction and Development·K D BoehmJ Ilan
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Apr 1, 1990·British Journal of Obstetrics and Gynaecology·B J VollenhovenD L Healy
Mar 1, 1989·American Journal of Obstetrics and Gynecology·K KawaguchiT Mori
May 15, 1982·American Journal of Obstetrics and Gynecology·J A OtubuP K Besch
Aug 1, 1995·American Journal of Obstetrics and Gynecology·P N RaukG Michalopoulos
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T YamamotoW A Border
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·R K SinghI J Fidler
Jun 1, 1995·American Journal of Obstetrics and Gynecology·E Y StrawnC L Bethea
Jan 1, 1995·American Journal of Obstetrics and Gynecology·M S ReinA J Friedman
Dec 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M BenezraI Vlodavsky
Apr 1, 1994·Obstetrics and Gynecology·L S WilcoxH B Peterson
Jan 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A NaglerI Vlodavsky
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·B S LeeR A Nowak
Sep 17, 1998·The Journal of Clinical Investigation·J A Oliver, Q Al-Awqati
Aug 30, 2000·Journal of the Society for Gynecologic Investigation·C L WalkerR Fuchs-Young
Nov 1, 1993·Trends in Cardiovascular Medicine·M Klagsbrun, S Dluz

❮ Previous
Next ❯

Citations

Nov 25, 2003·Biochemical and Biophysical Research Communications·John C M TsibrisWilliam N Spellacy
Oct 28, 2008·Seminars in Reproductive Medicine·Xiaoping Luo, Nasser Chegini
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A Di LietoG De Rosa
Nov 11, 2011·Journal de gynécologie, obstétrique et biologie de la reproduction·M KoskasJ Derrien
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Agnieszka ChrobakMałgorzata Jerzak
Mar 18, 2005·Cancer Genetics and Cytogenetics·Avery A Sandberg
May 14, 2014·Reproductive Sciences·Leo DohertyHugh Taylor
Feb 8, 2005·Journal of the Society for Gynecologic Investigation·Andrea Di LietoStefania Staibano
Jul 15, 2015·Menopause : the Journal of the North American Menopause Society·Shannon K Laughlin-TommasoElizabeth A Stewart
May 22, 2003·The American Journal of Pathology·Holly R MasonJohn J Castellot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Obstetrics and Gynecology
E A Stewart, R A Nowak
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
A KriplaniA K Saxena
© 2021 Meta ULC. All rights reserved