Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.

Nature Communications
Xiang ShuWei Zheng

Abstract

Known risk variants explain only a small proportion of breast cancer heritability, particularly in Asian women. To search for additional genetic susceptibility loci for breast cancer, here we perform a meta-analysis of data from genome-wide association studies (GWAS) conducted in Asians (24,206 cases and 24,775 controls) and European descendants (122,977 cases and 105,974 controls). We identified 31 potential novel loci with the lead variant showing an association with breast cancer risk at P < 5 × 10-8. The associations for 10 of these loci were replicated in an independent sample of 16,787 cases and 16,680 controls of Asian women (P < 0.05). In addition, we replicated the associations for 78 of the 166 known risk variants at P < 0.05 in Asians. These findings improve our understanding of breast cancer genetics and etiology and extend previous findings from studies of European descendants to Asian women.

References

Apr 21, 2001·Biometrics·B Devlin, K Roeder
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Valerie A McCormack, Isabel dos Santos Silva
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jan 14, 2009·Genetic Epidemiology·Rui Xiao, Michael Boehnke
Jul 10, 2010·Bioinformatics·Cristen J WillerGonçalo R Abecasis
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
May 11, 2011·Nature Communications·Lizhi HeDamu Tang
Feb 9, 2012·Breast Cancer Research : BCR·Ana Cv KrepischiCarla Rosenberg
Feb 16, 2013·Journal of the National Cancer Institute·Jirong LongWei Zheng
Jan 29, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yanfeng ZhangWei Zheng
Sep 15, 2014·Nature Genetics·Ali Amin Al OlamaChristopher A Haiman
Oct 14, 2014·Nature Communications·Eduard SchulzHeinz Sill
Nov 14, 2014·Clinical & Experimental Metastasis·Andy C-M ChangRobin L Anderson
Jan 22, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Shiovitz, L A Korde
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Mar 12, 2016·Gastroenterology·Chenjie ZengWei Zheng
Feb 10, 2017·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Paul KalitsisDamien F Hudson
Oct 24, 2017·Nature·Kyriaki MichailidouDouglas F Easton
Feb 23, 2018·Cell Division·Hong-Zhen WangXudong Cao
Aug 11, 2018·Nature Communications·Tracy A O'MaraDeborah J Thompson

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Citations

Sep 26, 2020·Nature Reviews. Clinical Oncology·Ophira GinsburgPaul Brennan
Mar 27, 2021·Journal of the National Cancer Institute·Kathleen E Houlahan
Mar 27, 2021·Journal of the National Cancer Institute·Zhaohui DuChristopher A Haiman

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Methods Mentioned

BETA
genotyping
chip
exome sequencing

Software Mentioned

HaploReg
MEGA
R
Sequenom
Roadmap
PLINK2
GCTA
METAL
lme4
MR

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