PMID: 9182820Jun 1, 1997Paper

Identification of novel cadherins expressed in human melanoma cells

The Journal of Investigative Dermatology
Norihisa MatsuyoshiS Imamura

Abstract

Cadherin molecules are essential for tissue morphogenesis and are also related to cancer invasion and metastasis. Although normal melanocytes express E- and P-cadherin, the activity and expression of E- and P-cadherin in melanoma cells are still unknown. We measured the homophilic adhesion activity of human normal epidermal melanocytes and the melanoma cell lines MeWo and A375. The melanoma cells showed stronger homophilic adhesion activity than did the melanocytes, despite the lower expression of E- and P-cadherin in the melanoma cells. This result suggested that melanoma cells expressed other types of homophilic adhesion molecules. Using degenerate primers to amplify multiple cadherin subtypes, we performed a polymerase chain reaction (PCR) with the first strand of cDNAs generated by reverse transcription of the mRNAs of the melanoma cells, and we isolated two known cadherin fragments, N-cadherin and PC42, and six novel cadherin fragments, cadherins ME1-ME6. The reverse transcriptase-PCR using specific primers of cadherins including E-, P-, and N-cadherins, PC42, and cadherins ME1-ME6 revealed that the melanoma cells expressed more kinds of cadherin molecules than did the melanocytes. Such cadherins may play an important role...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·H OkaS Hirano
Jan 21, 1991·International Journal of Cancer. Journal International Du Cancer·D R WelchM J Hendrix
Apr 1, 1991·The Journal of Cell Biology·U H FrixenW Birchmeier
Sep 1, 1990·Journal of Neurochemistry·F S WalshP N Goodfellow
Aug 1, 1981·The British Journal of Dermatology·S Kondo, K Aso
Oct 1, 1993·Current Opinion in Cell Biology·M Takeichi

❮ Previous
Next ❯

Citations

Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Georgia M BeasleyDouglas S Tyler
Oct 13, 2001·Journal of Cellular Physiology·P PlaL Larue
Mar 30, 2004·The Journal of Biological Chemistry·Casimiro Castillejo-LópezStefan Baumgartner
Sep 17, 2016·AAPS PharmSciTech·Enrique Martínez-CamposInmaculada Aranaz
May 17, 2008·Cancer Research·Christina K AugustineDouglas S Tyler
May 15, 2007·The Journal of Investigative Dermatology·Christian J SchmittWiebke K Peitsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Biochemical and Biophysical Research Communications
Norihisa Matsuyoshi, S Imamura
Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Kentaro YokoiHisashi Yamada
© 2021 Meta ULC. All rights reserved