Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

Cancer Letters
Annalisa PezzoloMaria Luisa Garrè

Abstract

Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. Tumor DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). The novel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2-q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.

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Citations

Jun 19, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Stephen C Mack, Michael D Taylor
Feb 11, 2012·Acta Neuropathologica·Khalida WaniUNKNOWN Collaborative Ependymoma Research Network
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Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Alessia PicaDamien C Weber
Jul 25, 2008·Journal of Cellular Physiology·Matthias KarajannisElizabeth W Newcomb
Nov 13, 2018·Future Oncology·Soumen KhatuaStephen C Mack
Nov 2, 2013·Journal of Neuro-oncology·Rakesh Kumar GuptaChitra Sarkar
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew M DonsonNicholas K Foreman
Jun 18, 2009·Molecular Cancer Research : MCR·John-Paul KildayRichard Grundy

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