Identification of novel ethanol-sensitive genes by expression profiling

Pharmacology & Therapeutics
S Rahman, Michael F Miles

Abstract

Chronic exposure to ethanol or other addicting drugs causes long-lasting, deleterious behavioral responses, such as tolerance, dependence, sensitization, and addiction. Changes in brain gene expression are thought to be a critical component of these behavioral adaptations. Our laboratory and others have utilized cultured neuronal cells as model systems for studying gene regulation by ethanol. Recently, the use of non-biased, high-throughput approaches to studying gene expression has allowed identification of gene regulation "patterns," rather than single genes responding to ethanol. This review will discuss how expression-profiling approaches can be used to identify functional changes occurring in neural cells with chronic exposure to ethanol.

References

Apr 14, 1992·Biochimica Et Biophysica Acta·M F MilesV DeGuzman
Jan 1, 1990·Annals of Medicine·M K Ticku
Jan 1, 1990·Annals of Medicine·D M LovingerF F Weight
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P D SuzdakS M Paul
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R O MessingD A Greenberg
Apr 1, 1994·Brain Research. Molecular Brain Research·H J van de VeldeW J Van de Ven
Dec 1, 1995·Journal of Neurochemistry·C MontoliuC Guerri
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M F MilesM Elliott
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Schröder, M J Lohse
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchenaR W Davis
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·C W HodgeA S Aiken
May 9, 1997·The Journal of Biological Chemistry·C ThibaultM F Miles
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·E Spanakis, D Brouty-Boyé
Oct 6, 1997·Science·G F Koob, M Le Moal
Oct 6, 1997·Science·E J Nestler, G K Aghajanian
Oct 23, 1997·Genome Research·S Audic, J M Claverie
Dec 6, 1997·Biochemical and Biophysical Research Communications·I J LeeB J Song
May 13, 1998·Neurologic Clinics·J C Brust
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Sep 10, 1998·Nature Genetics·O ErmolaevaM S Boguski
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Jan 9, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·G L SchaferK M Wiren
Jan 23, 1999·Nature Genetics·E SouthernM Shchepinov
Feb 4, 1999·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M Vingron, J Hoheisel
Mar 10, 1999·Journal of the National Cancer Institute·J Wittes, H P Friedman
Mar 10, 1999·Journal of the National Cancer Institute·S G HilsenbeckS A Fuqua
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·P TamayoT R Golub
Apr 9, 1999·Alcoholism, Clinical and Experimental Research·L FanP A Wilce
Jun 1, 1999·Methods in Enzymology·J E KacharminaJ Eberwine
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·U AlonA J Levine

❮ Previous
Next ❯

Citations

Dec 7, 2007·Genome Génome / Conseil National De Recherches Canada·Shiva M SinghRaihan K Uddin
Mar 21, 2006·BMC Bioinformatics·Richard E KennedyMichael F Miles
Jul 16, 2010·Journal of Neurochemistry·Steven D HicksMichael W Miller
Jan 4, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Maia L GreenThomas B Knudsen
Aug 26, 2014·Frontiers in Genetics·Susan M SmithGeorge R Flentke
Jul 9, 2004·Neuroscience Research·Kazuya IwamotoTadafumi Kato
Apr 26, 2005·Addiction Biology·Christelle ThibaultMichael Miles
Nov 25, 2003·Journal of Chemical Information and Computer Sciences·Zheng Rong Yang, Kuo-Chen Chou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.