Identification of novel heparin-binding domains of vitronectin

FEBS Letters
O D LiangK T Preissner

Abstract

Vitronectin is a multifunctional serum protein which provides a unique regulatory link between cell adhesion, humoral defense mechanism and the hemostatic system, and the heparin-binding properties of vitronectin are thought to have participated in various functional aspects. In addition to the carboxy-terminal glycosaminoglycan-binding motif, we report on two novel heparin-binding domains which were identified using phage display technique. One heparin-binding domain is located between amino acids Asp82 and Cys137 at the end of the connector region, while the other is in the second hemopexin-type repeat, between amino acids Lys175 and Asp219 of the vitronectin molecule. Our findings may shed new light to the activities of vitronectin and its binding to cells, which could not be explained solely on the basis of the known heparin-binding domain.

References

Jan 1, 1991·Annual Review of Cell Biology·K T Preissner
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C F BarbasS J Benkovic
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A S KangR A Lerner
Jan 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A D Cardin, H J Weintraub

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Citations

Jul 5, 2001·Archives of Biochemistry and Biophysics·R E EdensJ M Weiler
Jun 4, 1998·Thrombosis Research·K T Preissner, D Seiffert
Jan 18, 2006·Journal of Biomaterials Science. Polymer Edition·Giyoong TaeAllan S Hoffman
Sep 3, 2010·Molecular Microbiology·Birendra SinghKristian Riesbeck
Nov 17, 2009·International Journal of Laboratory Hematology·F NewallP Monagle
Dec 19, 2003·Cell Communication & Adhesion·Cynthia E Wilkins-PortPaula J McKeown-Longo
Jun 9, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vladimir Bobek, Josef Kovarík
Jul 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmKristian Riesbeck
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teresia HallströmKristian Riesbeck

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