Identification of novel homologous microRNA genes in the rhesus macaque genome

BMC Genomics
Junming YueKyle E Orwig

Abstract

MicroRNAs (miRNAs) are about 22 nucleotide (nt) endogenous small RNAs that negatively regulate gene expression. They are a recently described class of regulatory molecules that has biological implications for tumorigenesis, development, metabolism and viral diseases. To date, 533 miRNAs have been identified in human. However, only 71 miRNAs have been reported in rhesus macaque. The rhesus is widely used in medical research because of its genetic and physiological similarity to human. The rhesus shares approximately 93% similarity with human in genome sequences and miRNA genes are evolutionarily conserved. Therefore, we searched the rhesus genome for sequences similar to human miRNA precursor sequences to identify putative rhesus miRNA genes. In addition to 71 miRNAs previously reported, we identified 383 novel miRNA genes in the rhesus genome. We compared the total 454 miRNAs identified so far in rhesus to human homologs, 173 miRNA genes showed 100% homology in precursor sequences between rhesus and human; The remaining 281 show more than 90%, less than 100% homology in precursor sequences. Some miRNAs in the rhesus genome are present as clusters similar to human, such as miR-371/373, miR-367/302b, miR-17/92, or have multiple c...Continue Reading

References

Mar 1, 1988·Computer Applications in the Biosciences : CABIOS·E W Myers, W Miller
Aug 26, 1998·Current Biology : CB·C B Stewart, T R Disotell
Oct 27, 2001·Science·M Lagos-QuintanaT Tuschl
Apr 5, 2002·Genome Research·W James Kent
Jun 5, 2002·Genome Research·W James KentDavid Haussler
Dec 20, 2002·Nature·Carina Dennis
Jan 10, 2003·Nucleic Acids Research·D KarolchikUNKNOWN University of California Santa Cruz
Jan 30, 2003·RNA·Mariana Lagos-QuintanaThomas Tuschl
Jan 30, 2003·RNA·Josée DostieGideon Dreyfuss
Feb 20, 2003·RNA·Victor AmbrosThomas Tuschl
Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Aug 16, 2003·Developmental Cell·Hristo B HoubaviyPhillip A Sharp
Oct 18, 2003·Seminars in Cancer Biology·Michael T McManus
Dec 19, 2003·Genes & Development·Rui YiBryan R Cullen
Dec 19, 2003·Nucleic Acids Research·Sam Griffiths-Jones
Jun 9, 2004·Developmental Biology·Mi-Ra SuhKye-Seong Kim
Sep 17, 2004·Nature·Victor Ambros
Nov 9, 2004·Nature·Richard I GregoryRamin Shiekhattar
Nov 9, 2004·Nature·Ahmet M DenliGregory J Hannon
Jan 7, 2005·The FEBS Journal·Michel J Weber
May 14, 2005·Nucleic Acids Research·Yael AltuviaHanah Margalit
Jun 10, 2005·Nature·Lin HeScott M Hammond
Jun 24, 2005·Nature·Thimmaiah P ChendrimadaRamin Shiekhattar
Oct 21, 2005·BioTechniques·Rui Shi, Vincent L Chiang
Nov 15, 2005·Nature Cell Biology·Andrew JakymiwEdward K L Chan
Dec 31, 2005·Nucleic Acids Research·Sam Griffiths-JonesAnton J Enright
Mar 15, 2006·Journal of Biotechnology·Jens ReederRobert Giegerich
Jul 19, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Rick ConradLance P Ford
Aug 1, 2006·Nature Genetics·Michael DewsAndrei Thomas-Tikhonenko
Aug 17, 2006·Journal of Virology·Joan BurnsideRobin W Morgan
Aug 31, 2006·Molecular and Cellular Biology·Anwar HossainGrady F Saunders
Apr 10, 2007·Genome Research·Rui ZhangBing Su
Apr 14, 2007·Science·UNKNOWN Rhesus Macaque Genome Sequencing and Analysis ConsortiumAnn S Zwieg
Dec 29, 2015·Journal of Bioinformatics and Computational Biology·Cong PianLiang-Yun Zhang

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Citations

Mar 29, 2012·Genome Biology and Evolution·Michael DannemannJanet Kelso
Jun 6, 2009·Molecular Biology and Evolution·Peter F StadlerKerstin Ullmann
Jul 3, 2010·Journal of Biomedical Science·Genesio M KarereLaura A Cox
Feb 7, 2009·BMC Genomics·Alavala Matta ReddyRamanjulu Sunkar
Jul 2, 2010·BMC Genomics·Ning-Yi ShaoPhilipp Khaitovich
Mar 29, 2012·BMC Genomics·Michael DannemannJanet Kelso
Mar 11, 2010·BMC Research Notes·Markus Brameier
Jan 17, 2013·Environmental Health Perspectives·Julia E RagerRebecca C Fry
Dec 24, 2010·PloS One·Manoj M PillaiBeverly Torok-Storb
Sep 2, 2008·Computational Biology and Chemistry·Vesselin BaevIvan Minkov
Jul 6, 2017·Aging Cell·Augusto SchneiderRozalyn M Anderson
Jul 22, 2015·Infection and Immunity·Ryan M McAdamsKristina M Adams Waldorf
Apr 3, 2019·Nucleic Acids Research·Tobias FehlmannAndreas Keller
Aug 24, 2021·BioMed Research International·Zhi-Xin LiYong-Qing Zeng

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Methods Mentioned

BETA
PCR

Software Mentioned

MFOLD

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