Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV

Acta Tropica
Juliana Helena S BarrosAna Maria Jansen

Abstract

Trypanosoma cruzi is a parasitic protozoan responsible for Chagas disease. Seven different Discrete Typing Units (DTUs) of T. cruzi are currently identified in nature: TcI-TcVI, and TcBat whose distribution patterns in nature, hosts/reservoirs and eco-epidemiological importance are still little known. Here, we present novel data on the geographic distribution and diversity of mammalian hosts and vectors of T. cruzi DTUs TcIII and TcIV. In this study, we analyzed 61 T. cruzi isolates obtained from 18 species of mammals (five orders) and two Hemiptera genera. Samples were collected from five Brazilian biomes (Pantanal, Caatinga, Cerrado, Atlantic Rainforest, and Amazon) previously characterized as Z3 or mixed infection (TcI-Z3) by mini-exon gene PCR. To identify TcIII and TcIV genotypes, we applied restriction fragment length polymorphism analysis to the PCR-amplified histone 3 gene. DTUs TcIII and TcIV were identified in single and mixed infections from wide dispersion throughout five Brazilian biomes studied, with TcIV being the most common. Pantanal was the biome that displayed the largest number of samples characterized as TcIII and TcIV in single and mixed infections, followed by Atlantic Rainforest and Amazon. Species from ...Continue Reading

Citations

Nov 30, 2019·Clinical Microbiology Reviews·Caryn BernJames H Maguire
Sep 8, 2018·Parasites & Vectors·Ana Maria JansenAndré Luiz Rodrigues Roque
May 28, 2020·Frontiers in Cellular and Infection Microbiology·Santiago J MartinezDavid M Engman
Sep 24, 2020·Transboundary and Emerging Diseases·Danilo KluyberAndré L R Roque
Mar 9, 2019·International Journal for Parasitology. Parasites and Wildlife·Marina Silva RodriguesAna Maria Jansen
Jul 6, 2021·Frontiers in Veterinary Science·Keneth Iceland KasoziSusan Christina Welburn

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