Identification of novel pleiotropic gene for bone mineral density and lean mass using the cFDR method.

Annals of Human Genetics
Li-Jun TanHong-Wen Deng

Abstract

Bone mineral density (BMD) and whole-body lean mass (WBLM) are two important phenotypes of osteoporosis and sarcopenia. Previous studies have shown that BMD and lean mass were phenotypically and genetically correlated. To identify the novel common genetic factors shared between BMD and WBLM, we performed the conditional false discovery rate (cFDR) analysis using summary data of the genome-wide association study of femoral neck BMD (n = 53,236) and WBLM (n = 38,292) from the Genetic Factors for Osteoporosis Consortium (GEFOS). We identified eight pleiotropic Single Nucleotide Polymorphism (SNPs) (PLCL1 rs11684176 and rs2880389, JAZF1 rs198, ADAMTSL3 rs10906982, RFTN2/MARS2 rs7340470, SH3GL3 rs1896797, ST7L rs10776755, ANKRD44/SF3B1 rs11888760) significantly associated with femoral neck BMD and WBLM (ccFDR < 0.05). Bayesian fine-mapping analysis showed that rs11888760, rs198, and rs1896797 were the possible functional variants in the ANKRD44/SF3B1, JAZF1i, and SH3GL3 loci, respectively. Functional annotation suggested that rs11888760 was likely to comprise a DNA regulatory element and linked to the expression of RFTN2 and PLCL1. PLCL1 showed differential expression in laryngeal posterior cricoarytenoid muscle between rats of 6 mo...Continue Reading

References

Oct 30, 2001·Behavioural Brain Research·Y BenjaminiI Golani
Feb 12, 2002·International Review of Cytology·Masahito WatanabeHana Hayasaki
Mar 24, 2004·Experimental Gerontology·Stephen WelleCharles A Thornton
Jan 13, 2005·The Journal of Biological Chemistry·Xuena LinGyörgy Hajnóczky
Feb 3, 2005·Physiological Genomics·Paul G GiresiSusan C Kandarian
Oct 22, 2005·Journal of Applied Physiology·Colleen A McMullen, Francisco H Andrade
Nov 4, 2005·American Journal of Physiology. Cell Physiology·Ryan C RiddleHenry J Donahue
Apr 9, 2008·Nature Genetics·Michael N WeedonTimothy M Frayling
Nov 20, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carrie CaulkinsHoward Winet
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiang-Ding ChenHong-Wen Deng
May 1, 2010·Endocrine Reviews·Stuart H Ralston, André G Uitterlinden
Dec 25, 2010·Cell Biochemistry and Biophysics·Ole KjaerulffAnita Jung
Apr 1, 2011·Lancet·Tilman D RachnerLorenz C Hofbauer
Jul 1, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Dawson-HughesL J Melton
Jul 5, 2011·Neuropathology and Applied Neurobiology·S DelicM J Riemenschneider
Mar 29, 2012·Advances in Experimental Medicine and Biology·Hiroshi Kajiya
Feb 6, 2013·PLoS Genetics·Sophie GarnierDavid-Alexandre Trégouët
Aug 29, 2013·Arthritis and Rheumatism·Frederick W MillerUNKNOWN Myositis Genetics Consortium
Aug 31, 2013·Endocrine·Luisella Cianferotti, Maria Luisa Brandi
Mar 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jian HuangDavid Karasik
Apr 19, 2015·Bone·M H EdwardsC Cooper
Oct 11, 2015·Bone·Marco Brotto, Lynda Bonewald
Mar 6, 2016·Cell Calcium·Michelle K TuLaura N Borodinsky
May 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Gregory LivshitsTim D Spector
Jul 21, 2017·Nature Communications·M Carola ZillikensDouglas P Kiel
Jul 22, 2017·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Ana C AntunesTeresa F Amaral
Sep 14, 2017·International Journal of Molecular Medicine·Shengjie LiZhen Yang
Nov 23, 2017·Diabetes Research and Clinical Practice·Byambatseren JambaljavNobuya Inagaki
Jan 6, 2018·American Journal of Human Genetics·Carolina Medina-GomezFernando Rivadeneira
Apr 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ken-Ichiro TanakaDavid Goltzman
Apr 29, 2018·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Taishi MidorikawaShizuo Sakamoto
Jul 24, 2018·Journal of the American Medical Directors Association·Médéa LocquetOlivier Bruyère
Jan 1, 2019·American Journal of Human Genetics·Gleb KichaevAlkes L Price

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