Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity

Journal of Pharmaceutical and Biomedical Analysis
Hideto KimuraKazushige Yokota

Abstract

Natural seeds of Japanese horse chestnut (Aesculus turbinata Blume) contain large amounts of mixed triterpenoidal saponins called escins. Recent studies have shown that escins have several biological activities including anti-inflammatory action and inhibitory effects on the absorption of ethanol and glucose. For the edible utilization of the seeds, natural seeds are usually treated with wooden ashes to remove harshness. Here, we found the novel compounds derived from escins in the edible seeds after the food processing with wooden ashes. The instrumental analyses revealed the chemical structures of escins and the derivatives. These compounds are identified as four types of deacetylescins Ia, IIa, Ib, and IIb as well as two types of desacylescins I and II. To determine their biological activity, the purified compounds were tested for their potential nutraceutical activity. The oral glucose tolerance test in mice revealed that a single oral administration of the isolated components of deacetylescins at a dose of 100 mg/kg was clearly effective in attenuating the elevation of blood glucose levels. The inhibitory effects of escins and their derivatives were in the order of escins>deacetylescins>desacylescins. Moreover, we found th...Continue Reading

References

Dec 22, 1999·Chemical & Pharmaceutical Bulletin·Z ZhangJ Zheng
Sep 1, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C R Sirtori
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L K HanH Okuda
Aug 13, 2003·Bioscience, Biotechnology, and Biochemistry·Chong-Suk KwonJong-Sang Kim

❮ Previous
Next ❯

Citations

Aug 5, 2009·Biological & Pharmaceutical Bulletin·Noemí BoquéJosé Alfredo Martinez
Jan 8, 2008·Chemical & Pharmaceutical Bulletin·Jiang-Ning HuYi-Nan Zheng
Feb 8, 2007·Bioscience, Biotechnology, and Biochemistry·Darika KongritKazushige Yokota
Jan 1, 2010·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Sonia A TucciJason Cg Halford
Dec 21, 2010·Journal of Pharmaceutical and Biomedical Analysis·J BernalA Cifuentes
Jan 8, 2016·Obesity Research & Clinical Practice·Meriga BalajiSreenivasulu Dasari
Oct 16, 2007·Drug Discovery Today·Rahul B Birari, Kamlesh K Bhutani
Dec 20, 2011·Phytochemistry·Wei YuanShiyou Li
May 1, 2012·Food Chemistry·Om P SharmaTej K Bhat
May 3, 2014·Journal of Molecular Neuroscience : MN·Govindasamy Pushpavathi SelvakumarNamasivayam Elangovan
Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariangela MarrelliGiancarlo A Statti
Jan 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lenka VarinskáPeter Gál
Jun 7, 2018·Rapid Communications in Mass Spectrometry : RCM·Corentin DecrooPascal Gerbaux
Jul 9, 2011·Natural Product Reports·Ilze VermaakJosias H Hamman
Jun 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mubasher HussainDongliang Qiu
Jan 31, 2021·Life Sciences·Ashwani Kumar, Shilpi Chauhan
Feb 12, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Logesh RajanSuresh Kumar Mohankumar
May 22, 2021·Journal of Natural Medicines·Zhao ZhuoyueEisuke Kato
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Avez SharipovJamoliddin Razzokov
Aug 14, 2018·Molecular Pharmaceutics·Ramsia SreijThomas Hellweg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.