Identification of octopaminergic neurons that modulate sleep suppression by male sex drive

ELife
Daniel R MachadoKyunghee Koh

Abstract

Molecular and circuit mechanisms for balancing competing drives are not well understood. While circadian and homeostatic mechanisms generally ensure sufficient sleep at night, other pressing needs can overcome sleep drive. Here, we demonstrate that the balance between sleep and sex drives determines whether male flies sleep or court, and identify a subset of octopaminergic neurons (MS1) that regulate sleep specifically in males. When MS1 neurons are activated, isolated males sleep less, and when MS1 neurons are silenced, the normal male sleep suppression in female presence is attenuated and mating behavior is impaired. MS1 neurons do not express the sexually dimorphic FRUITLESS (FRU) transcription factor, but form male-specific contacts with FRU-expressing neurons; calcium imaging experiments reveal bidirectional functional connectivity between MS1 and FRU neurons. We propose octopaminergic MS1 neurons interact with the FRU network to mediate sleep suppression by male sex drive.

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Citations

Dec 6, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ada Eban-RothschildLuis de Lecea
Sep 13, 2017·ELife·Esteban J BeckwithGiorgio F Gilestro
Oct 7, 2017·ELife·Bethany A Stahl, Alex C Keene
Mar 12, 2020·PLoS Genetics·Elizabeth B BrownAlex C Keene
Jun 14, 2018·The Journal of Experimental Biology·Alex C Keene, Erik R Duboue
Oct 2, 2019·Frontiers in Physiology·Esteban J Beckwith, Alice S French
Jan 13, 2021·Current Biology : CB·Orie T Shafer, Alex C Keene
Jan 1, 2019·Bio-protocol·Margaret E DriscollDivya Sitaraman
Nov 6, 2018·Current Opinion in Physiology·Kenta Asahina
Dec 5, 2021·FEBS Letters·Evrim YildirimDae-Sung Hwangbo
Dec 16, 2021·The FEBS Journal·José Manuel DuhartKyunghee Koh

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