Identification of odors, faces, cities and naming of objects in patients with subjective cognitive decline, mild cognitive impairment and Alzheimer´s disease: a longitudinal study

International Psychogeriatrics
R TahmasebiJohann Lehrner

Abstract

ABSTRACTObjective:Recent studies have tried to find a reliable way of predicting the development of Alzheimer´s Disease (AD) among patients with mild cognitive impairment (MCI), often focusing on olfactory dysfunction or semantic memory. Our study aimed to validate these findings while also comparing the predictive accuracy of olfactory and semantic assessments for this purpose. Six hundred fifty patients (median age 68, 58% females) including controls, SCD (subjective cognitive decline), non-amnestic MCI (naMCI), amnestic MCI (aMCI), and AD patients were tested for olfactory dysfunction by means of odor identification testing and semantic memory. Of those 650 patients, 120 participants with SCD, naMCI, or aMCI at baseline underwent a follow-up examination after two years on average. Of these 120 patients, 12% had developed AD at follow-up (converters), while 88% did not develop AD at follow-up (non-converters). Analysis showed a significant difference only for initial olfactory identification between converters and non-converters. Sensitivity of impairment of olfactory identification for AD prediction was low at 46.2%, although specificity was high at 81.9%. Semantic memory impairment at baseline was not significantly related ...Continue Reading

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Citations

Jul 15, 2020·International Journal of Geriatric Psychiatry·Tatiana BelfortMarcia Cristina Nascimento Dourado
Sep 7, 2020·International Journal of Geriatric Psychiatry·Simon CloutierSylvie Belleville
Oct 24, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Manuel Montero-OdassoRichard Camicioli
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Benoît JobinBenjamin Boller

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