PMID: 9428492Jan 15, 1998Paper

Identification of oncofetal fibronectin in patients with advanced epithelial ovarian cancer: detection in ascitic fluid and localization to primary sites and metastatic implants

Cancer
A W MenzinR F Feinberg

Abstract

The mechanisms by which metastatic ovarian cancer adheres to peritoneal surfaces are not well understood. A role for tumor-derived extracellular matrix adhesive molecules such as fibronectin (FN) has been proposed. Because oncofetal fibronectin (onfFN) isoforms function in the adhesion of trophoblasts and have been identified in association with several malignancies, we sought to study onfFN in patients with advanced epithelial ovarian cancer. Total FN was identified with the nonspecific anti-FN monoclonal antibody CAF. OnfFN was identified using the specific monoclonal antibodies FDC-6 and X18A4. These antibodies were applied to: 1) ascitic fluid from advanced epithelial ovarian cancer patients and peritoneal fluid from patients without pathologic conditions and 2) tissue sections of primary lesions and metastatic ovarian cancer implants. Comparative histologic specimens included normal ovarian tissue and small bowel implants of endometriosis. When measured by sandwich enzyme-linked immunoadsorbent assay, all peritoneal fluids (32 malignant and 32 benign) contained marked quantities of total (CAF reactive) FN, although malignant ascites had higher concentrations than benign samples (173.2 +/- 36.8 microg/mL vs. 76.4 +/- 31.8 m...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R E SeftorM J Hendrix
Dec 2, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·G NicolòL Zardi
Sep 1, 1991·The American Review of Respiratory Disease·D C DeanS J Weintraub
Nov 1, 1986·The Journal of Cell Biology·P CastellaniL Zardi
May 1, 1995·American Journal of Obstetrics and Gynecology·R F FeinbergC L Wang
Aug 1, 1995·Gynecologic Oncology·S A CannistraJ DiCarlo
Jan 1, 1996·CA: a Cancer Journal for Clinicians·S L ParkerP A Wingo

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Citations

Oct 13, 2015·Clinical & Experimental Metastasis·Shanna A ArnoldAndries Zijlstra
Jul 12, 2007·Seminars in Immunopathology·Berthold Huppertz
May 18, 2012·American Journal of Reproductive Immunology : AJRI·Berthold HuppertzMartin Gauster
Aug 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lu-Min ChenYu-Jia Chang
May 21, 2019·Frontiers in Cell and Developmental Biology·Tianyi LiuYuhang Zhang
Apr 4, 2008·Journal of Cancer Research and Clinical Oncology·Petra RichterHeiko Wunderlich
Jan 24, 2014·Molecular Cancer Research : MCR·Fayth L Miles, Robert A Sikes
Apr 8, 2015·Bioconjugate Chemistry·Zheng HanZheng-Rong Lu
Dec 6, 2001·The American Journal of Pathology·R C CaseyA P Skubitz

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