Identification of Patient Characteristics Associated With SARS-CoV-2 Infection and Outcome in Kidney Transplant Patients Using Serological Screening.

Transplantation
Michelle WillicombeICHNT Renal COVID Group

Abstract

From population studies, solid organ transplant recipients are at increased risk of mortality from RT-PCR confirmed COVID-19 infection. The risk factors associated with infection acquisition and mortality in transplant recipients using serological data have not been reported. From 1725 maintenance transplant recipients, 855 consecutive patients were screened for SARS-CoV-2 antibodies. Serological screening utilized assays to detect both the N protein and receptor binding domain antibodies. Thirty-three of 855 (3.9%) of the screened patients had prior infection confirmed with RT-PCR. Twenty-one additional patients from our 1725 maintenance cohort with RT-PCR confirmed infection were included in our analysis. Eighty-nine of 855 (10.4%) patients tested positive for SARS-CoV-2 antibodies. Fifty-nine of 89 (66.3%) cases were patients newly identified as exposed, while 30/89 (33.7%) seropositive patients had previous infection confirmed by RT-PCR. A diagnosis of SARS-CoV-2 (RT-PCR or Ab+) was associated with being from a noncaucasoid background, P = 0.015; having a diagnosis of diabetes, P = 0.028 and a history of allograft rejection, P < 0.01. Compared with the RT-PCR+ cohort, patients with serological-proven infection alone were mo...Continue Reading

References

Nov 21, 2008·Kidney International·Jon J SnyderBertram L Kasiske
Jan 17, 2014·Transplantation·Michelle WillicombeDavid Taube
Aug 29, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Samuel ChanDavid W Johnson
Oct 31, 2020·Journal of the American Society of Nephrology : JASN·Maria PrendeckiMichelle Willicombe

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Citations

Mar 11, 2021·Current Transplantation Reports·Varun K PhadkeNadine G Rouphael
Jul 22, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Refik GökmenFrank J M F Dor

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