Identification of patients at risk of acute rejection by pretransplantation and posttransplantation monitoring of soluble CD30 levels in kidney transplantation

Transplantation
Sule SengulBulent Erbay

Abstract

In this study, we investigated the impact of pre- and posttransplantation sCD30 monitoring on early (<6 months) acute rejection (AR) risk and analyzed the effect of different immunosuppressive regimens on posttransplantation sCD30 levels in kidney recipients. Fifty patients receiving kidney allograft and 10 healthy donors were included in this retrospective cohort study. Eight patients developed biopsy-proven AR (19%). In pretransplantation samples, patients showed a significantly higher sCD30 than healthy controls. The pretransplantation and posttransplantation (day-15) sCD30 levels were significantly elevated in rejecting patients compared to non-rejecting patients. No significant differences among immunosuppressive regimens were found in posttransplantation sCD30 levels. High pretransplantation and posttransplantation (day 15) sCD30 levels are associated with increased risk of early AR, and sCD30 can be another tool to evaluate immunological risk prior to kidney transplantation. There was no difference in immunosuppressive regimens used in this study on posttransplantation sCD30 levels at the first month.

References

Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Jan 17, 2002·Transplantation·Steffen PelzlCaner Süsal
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Caner SüsalGerhard Opelz
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Citations

Jan 15, 2009·International Urology and Nephrology·Mohsen NafarBehzad Eniollahi
Nov 26, 2009·Current Opinion in Organ Transplantation·Choli HartonoManikkam Suthanthiran
Jul 24, 2010·Nephrology·Katherine A BarracloughSteven J McTaggart
Aug 19, 2015·Clinical Biochemistry·Elena Crespo, Oriol Bestard
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Efthymios YpsilantisCraig J Taylor
Sep 4, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Joanna Ashton-ChessSophie Brouard
Dec 25, 2010·Journal of Medical Virology·Tanzina HaqueDorothy H Crawford
Nov 10, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Patricia Hirt-MinkowskiStefan Schaub
Oct 27, 2015·Therapeutic Drug Monitoring·Eberhard Wieland, Maria Shipkova
Mar 16, 2016·Therapeutic Drug Monitoring·Mercè BrunetMichael Oellerich
Aug 10, 2013·Transplant Immunology·Patricia C GrenziMaria Gerbase-Delima
Feb 24, 2015·Transplant Immunology·Patricia C GrenziMaria Gerbase-DeLima
Sep 14, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicJimmy Espinoza
Nov 7, 2017·Expert Review of Proteomics·Arjun Chakraborty, Minnie Sarwal

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